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小动物CT-SPECT双模态成像系统中CT几何畸变校正方法
引用本文:季栖凡,李军,曹文田,李军,包尚联.小动物CT-SPECT双模态成像系统中CT几何畸变校正方法[J].中国医学影像技术,2010,26(11):2179-2183.
作者姓名:季栖凡  李军  曹文田  李军  包尚联
作者单位:1. 北京大学医学物理和工程北京市重点实验室,北京,100871
2. 北京大学实验动物中心,北京,100871
基金项目:国家重点基础研究发展计划(973计划)项目(2006CB705705)、国家自然科学基金(60672104)、北京市共建项目(JD100010607)。
摘    要:目的 在北京大学医学物理和工程实验室研发的一个基于平板探测器的锥形束X线计算机断层扫描成像装置和单光子发射计算机断层扫描成像组成的双模态小动物成像系统中,提出一种用于校正机械系统不完善所引起的CT图像几何畸变的新方法。 方法 为系统建立一个笛卡尔坐标系,用鲍威尔算法对几何畸变参数进行计算。 结果 选取以平板探测器中心为坐标原点的坐标系统,所有几何参数均在该系统中进行定义,相应的几何畸变参数得到精确计算,基本上消除了几何伪影,经过校正后的重建图像质量有较大改善。 结论 该方法可有效校正小动物CT-SPECT双模态成像系统中CT图像的几何畸变,也适用于其他锥形束计算机断层扫描成像装置,并可作为单光子发射计算机断层扫描成像装置的几何畸变校正和双模态图像配准的基础。

关 键 词:体层摄影术  发射型计算机  单光子  体层摄影术  X线计算机  平板探测器
收稿时间:2010/4/30 0:00:00
修稿时间:6/3/2010 12:00:00 AM

CT geometrical deformation calibration method in animal dual-modality CT-SPECT system
JI Qi-fan,LI Jun,CAO Wen-tian,LI Jun and BAO Shang-lian.CT geometrical deformation calibration method in animal dual-modality CT-SPECT system[J].Chinese Journal of Medical Imaging Technology,2010,26(11):2179-2183.
Authors:JI Qi-fan  LI Jun  CAO Wen-tian  LI Jun and BAO Shang-lian
Institution:Beijing Key Laboratory of Medical Physics & Engineering,;Beijing Key Laboratory of Medical Physics & Engineering,;Beijing Key Laboratory of Medical Physics & Engineering,;Laboratory Animal Centre, Peking University, Beijing 100871, China;Beijing Key Laboratory of Medical Physics & Engineering,
Abstract:Objective To propose a new method, in order to correct the geometrical deformation existed in mechanism system in a flat-panel detector based on cone beam CT and pinhole SPECT assembled dual modality small animal CT-SPECT system developed in our laboratory. Methods A Cartesian coordinate system was defined for the dual modality small animal imaging system, the Powell algorithm was used to address the geometrical parameters. Results In the Cartesian coordinate system, origin was fixed on the center of flat-panel detector, and all geometrical parameters were defined and calculated. After the corrections, geometrical artifacts were removed effectively, and the quality of the image was greatly improved. Conclusion This method can accurately correct the geometrical deformations in dual modality small animal CT-SPECT system. This approach is also applicable to other cone-beam X-ray computed tomography imaging system, and it is also a solid base for SPECT geometrical correction, as well as the image registration between CT and SPECT images.
Keywords:Tomography  emission-computed  single-photon  Tomography  X-ray computed  Flat-panel detector
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