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超声血流动力学与血清标志物评价婴儿肝炎综合征肝纤维化程度
引用本文:李智贤,梁淡湄,王琳琳,何云,马韵,杨红,韦康来.超声血流动力学与血清标志物评价婴儿肝炎综合征肝纤维化程度[J].中国医学影像技术,2005,21(1):83-85.
作者姓名:李智贤  梁淡湄  王琳琳  何云  马韵  杨红  韦康来
作者单位:1. 广西医科大学第一附属医院超声科,广西,南宁,530021
2. 广西医科大学第一附属医院儿科,广西,南宁,530021
3. 广西医科大学第一附属医院病理科,广西,南宁,530021
摘    要:目的探讨超声血流动力学与血清肝纤维化标志物对婴儿肝炎综合征(IHS)肝纤维化程度的临床应用价值.方法超声检测41例IHS患儿肝脏血流动力学, 并检测血清肝纤维化标志物,按病理肝纤维化程度分组,进行单因素方差分析和相关分析.结果肝固有动脉收缩期峰值速度(PSV)和阻力指数(RI)、血清透明质酸(HA)测值在轻、中、重度肝纤维化组逐渐增高;与肝纤维化程度呈正相关(r分别为0.717、0.745和0.712,P=0.001);HV多普勒频谱波形改变与肝纤维化程度有较好的相关性(r=0.783,P<0.001).结论 PHA 的PSV和RI、血清HA浓度、HV多普勒频谱波形改变是反映IHS肝纤维化程度较敏感的指标.

关 键 词:婴儿肝炎综合征  肝纤维化  多普勒超声检查  血流动力学
文章编号:1003-3289(2005)01-0083-03
收稿时间:2004/9/15 0:00:00
修稿时间:2004年9月15日

Assessment of the degree of hepatic fibrosis using ultrasonography and serology in infant hepatitis syndrome
LI Zhi-xian,LIANG Dan-mei,WANG ling-ling,HE yun,MA Yun,YANG Hong and WEI Kang-lai.Assessment of the degree of hepatic fibrosis using ultrasonography and serology in infant hepatitis syndrome[J].Chinese Journal of Medical Imaging Technology,2005,21(1):83-85.
Authors:LI Zhi-xian  LIANG Dan-mei  WANG ling-ling  HE yun  MA Yun  YANG Hong and WEI Kang-lai
Institution:Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
Abstract:Objective To evaluate the practical value of hemodynamics on ultrasonography and serum fibrosis markers in assessing liver fibrosis in the patients with infant hepatitis syndrome (IHS) Methods Forty one cases of IHS were examined by ultrasonography, which was compared with the serum fibrosis indexes determined by radioimmunoassay. All cases with liver fibrosis were staged through liver biopsy, which were clarified into mild, moderate and severe groups based upon liver histopathological findings. Comparative and correlative analyses were carried out. Results PSV and RI of the proper hepatic arteries (PHA), serum hyaluronic acid (HA) showed a consecutive increase from mild to severe hepatic fibrosis and closely positive correlations with hepatic fibrosis in IHS groups ( r =0.717, 0.745 and 0.712, respectively, P =0.001), and Doppler waveform of HV was also significantly correlated with the degree of hepatic fibrosis in IHS groups ( r =0.783, P <0.001). Conclusion PSV and RI of PHA, serum HA are sensitive indicators in staging hepatic fibrosis in patients with IHS.
Keywords:Infant hepatitis syndrome  Hepatic fibrosis  Doppler ultrasonography  Hemodynamics
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