| 脑胶质瘤MGMT启动子甲基化影像学研究进展 |
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| 引用本文： | 宋双双,卢洁.脑胶质瘤MGMT启动子甲基化影像学研究进展[J].中国医学影像技术,2019,35(5):782-785. |
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| 作者姓名： | 宋双双 卢洁 |
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| 作者单位： | 首都医科大学宣武医院放射科, 北京 100053;磁共振成像脑信息学北京市重点实验室, 北京 100053,首都医科大学宣武医院放射科, 北京 100053;磁共振成像脑信息学北京市重点实验室, 北京 100053;首都医科大学宣武医院核医学科, 北京 100053 |
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| 基金项目： | 北京市医院管理局"登峰"计划专项经费（DFL20180802）。 |
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| 摘 要： | O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化是脑胶质瘤的重要分子生物学标志物,与脑胶质瘤的发生、诊断及预后关系密切。MRI、PET等影像学检查及影像组学方法能够获得反映脑胶质瘤结构、功能、代谢甚至分子水平改变的重要信息,有望于术前无创、准确预测MGMT启动子甲基化状态。本文就脑胶质瘤影像学特征与MGMT启动子甲基化关系的研究进展进行综述。
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| 关 键 词： | 神经胶质瘤 O6-甲基鸟嘌呤DNA甲基转移酶 磁共振成像 影像组学 |
| 收稿时间： | 2018/11/2 0:00:00 |
| 修稿时间： | 2019/3/18 0:00:00 |
Progresses in imaging study of MGMT promoter methylation in gliomas |
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| SONG Shuangshuang and LU Jie.Progresses in imaging study of MGMT promoter methylation in gliomas[J].Chinese Journal of Medical Imaging Technology,2019,35(5):782-785. |
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| Authors: | SONG Shuangshuang and LU Jie |
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| Institution: | Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China and Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China;Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China |
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| Abstract: | O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is an important molecular biomarker which plays a key role in tumor development and determine the molecular subtypes and prognosis of gliomas. Radiomics and imaging examinations like MR and PET can obtain information of morphology, function, metabolism and molecular alterations of gliomas, which may help comprehensively and non-invasively predict MGMT promoter methylation status in gliomas. The relationships between imaging features and MGMT promoter methylation status of gliomas were reviewed in this article. |
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| Keywords: | glioma O6-methylguanine-DNA methyltransferase magnetic resonance imaging radiomics |
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