18F-FDG PET/CT显像评估肺癌患者预后

目的 分析¹⁸F-FDG PET/CT评估肺癌患者预后的价值。方法 回顾性分析109例肺癌患者的¹⁸F-FDG PET/CT及临床资料，测量病灶最大标准摄取值（SUV_max），并计算SUV_max与肿瘤最大径（D）比值（SUV_max/D）。采用Kaplan-Merier法绘制生存曲线，以COX单因素及多因素回归模型分析肺癌患者无进展生存期及总生存期的影响因素。结果 109例患者SUV_max为1.50~34.90，中位数为7.90；SUV_max/D为1.88~6.86 cm^-1，中位数为1.90 cm^-1；中位总生存期22个月，中位无进展生存期19个月。单因素COX回归分析结果显示，SUV_max、临床分期、SUV_max/D是无进展生存期的影响因素，SUV_max、临床分期、D是总生存期的影响因素（P均<0.05）。多因素COX回归分析显示，SUV_max、临床分期是无进展生存期及总生存期的独立预测因子（P均<0.01）。结论 肺癌病灶SUV_max、SUV_max/D对患者生存期有预测价值；SUV_max可能作为生存期的独立预测因子。

18F-FDG PET/CT in prognostic evaluation of patients with lung cancer

Objective To investigate the prognostic value of ¹⁸F-FDG PET/CT in patients with lung cancer. Methods ¹⁸F-FDG PET/CT data and clinical data of 109 patients with lung cancer were retrospectively analyzed. The maximum standard value (SUV_max) of the lesion was measured, and the ratio of SUV_max to the largest tumor diameter (SUV_max/D) was calculated. Kaplan-Merier method was used to draw the survival curve, and COX univariate and multivariate regression models were used to analyze the impact factors of progression-free survival (PFS) and overall survival (OS) in patients with lung cancer. Results SUV_max of all 109 patients with lung cancer was 1.50-34.90, median SUV_max was 7.90, SUV_max/D was 1.88-6.86 cm^-1, median SUV_max/D was 1.90 cm^-1, median OS was 22 months, and median PFS was 19 months. Univariate COX regression analysis showed that SUV_max, clinical staging and SUV_max/D were the impact factors for PFS (all P<0.05), while SUV_max, clinical staging and the largest tumor diameter were the impact factors for OS (all P<0.01). Multivariate COX regression analysis showed that SUV_max and clinical stage were independent predictors of PFS and OS of patients with lung cancer (all P<0.01). Conclusion SUV_max and SUV_max/D of tumors have predictive value for prognosis of patients with lung cancer, and SUV_max may be an independent predictor of survival.