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| 对比剂稳态磁化率MR灌注成像评价大鼠C6胶质瘤抗血管生成治疗的疗效 | |
| 引用本文： | 牛洪涛,张文丽,郭启勇,于兵,马丽.对比剂稳态磁化率MR灌注成像评价大鼠C6胶质瘤抗血管生成治疗的疗效[J].中国医学影像技术,2010,26(3):425-428. |
| 作者姓名： | 牛洪涛 张文丽 郭启勇 于兵 马丽 |
| 作者单位： | 1. 秦皇岛市第一医院CT室,河北,秦皇岛,066000 2. 中国医科大学附属盛京医院放射科,辽宁,沈阳,110004 3. 中国医科大学附属盛京医院感染科,辽宁,沈阳,110004 |
| 摘 要： | 目的 探讨对比剂稳态磁化率MR成像技术评估大鼠C6胶质瘤抗血管生成治疗疗效的价值.方法 17只荷瘤大鼠随机分成治疗组(n=8)和对照组(n=9).治疗组腹腔注射人重组内皮抑素(10 mg/kg),对照组腹腔注射相同剂量的生理盐水,共7天.治疗前、后分别行MR检查,测量肿瘤周边区、肿瘤中央区及对侧相应正常脑实质区的血容量(BV)和血管管径指数(VSI_(MRI))值,并与病理结果相对照.结果 治疗后治疗组与对照组肿瘤体积差异有统计学意义(t=5.26,P<0.05).治疗后肿瘤中心区及周边区BV和VSI_(MRI)值均有下降,以肿瘤周边区下降更为明显(t=4.14、3.66,P均<0.01).结论 对比剂稳态磁化率MR成像技术评估人重组内皮抑素治疗鼠C6脑胶质瘤具有可行性,能够准确反映治疗前后肿瘤BV和VSI的变化. |
| 关 键 词： | 胶质瘤 内皮抑素 磁共振成像 血管生成 |
| 收稿时间： | 2009/9/16 0:00:00 |
| 修稿时间： | 2009/11/10 0:00:00 |
Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging |
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| NIU Hong-tao,ZHANG Wen-li,GUO Qi-yong,YU Bing and MA Li.Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging[J].Chinese Journal of Medical Imaging Technology,2010,26(3):425-428. | |
| Authors: | NIU Hong-tao ZHANG Wen-li GUO Qi-yong YU Bing and MA Li |
| Institution: | CT Room, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China;CT Room, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China;Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China;Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China;Department of Infection, Shengjing Hospital of China Medical University, Shenyang 110004, China |
| Abstract: | Objective To explore the of value steady-state susceptibility contrast-enhanced MRI(SSCE-MRI) in assessment of anti-angiogenesis therapy in rat C6 glioma.Methods Seventeen rats with the bearing-tumor were randomly divided into the therapy group(n =8) and the contrast group(n =9).Human-recombination endostatin(10 mg/kg) was injected to animals in therapy group,and saline of the same dose was injected to the contrast group for 7 days.Blood volume(BV) and vessel size index(VSI) were measured of tumors in perip... |
| Keywords: | Glioma Endostastin Magnetic resonance imaging Angiogenesis |
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