育龄妇女亚甲基四氢叶酸还原酶~MTHFR基因C677T，A1298C位点多态性与HR-HPV感染的相关性研究

目的　探讨育龄妇女亚甲基四氢叶酸还原酶（MTHFR）C677T,A1298C基因多态性与高危型人乳头瘤病毒（HR-HPV）感染的相关性。方法　收集2017年11月～2019年12月期间来天津市宝坻区人民医院孕检的育龄妇女所做HR-HPV及 MTHFR 多态性（包括C677T和A1298C）检测的样本资料共1 130例，比较MTHFR各代谢型之间HR-HPV的阳性率。结果　在MTHFR的三种代谢型中，弱代谢型是HR-HPV优势型别52型（χ2=4.764，P=0.029,OR=1.771，95%CI:1.054~2.975）、16型（χ2=4.304，P=0.038,OR=1.922，95%CI:1.027~3.599）及多重感染（χ2=3.985，P=0.046,OR=1.479，95%CI:1.005~2.176）的易感型别。结论　MTHFR 代谢活性受C677T和A1298C位点基因的双重影响，其中的弱代谢型是HR-HPV优势型别52型和16型，以及多重感染的易感型别。

Study of the Relationship between MTHFR(C677T,A1298C)Polymorphism and HR-HPV Infection in Women of Childbearing Age

Objective To explore the relationship between MTHFRC677T and A1298C polymorphism and HR-HPV infection in women of childbearing age.Methods 1130 women of reproductive age in Tianjin Baodi Hospital tested for MTHFR C677T and A1298C polymorphism and HR-HPV infection from November 2017 to December 2019 were enrolled,and the positivity of HR-HPV among three groups of the gene expression pattern for MTHFR were compared.Results The weak metabolic group of MTHFR were susceptible to the HPV dominant type 52(χ²=4.764,P=0.029,OR=1.771,95%CI:1.054~2.975)and 16(χ²=4.304,P=0.038,OR=1.922,95%CI:1.027~3.599)infection,and to HPV multiple infection as well(χ²=3.985,P=0.046,OR=1.479,95%CI:1.005~2.176).Conclusion C677T and A1298C polymorphism has a double effect on metabolic activity of MTHFR,and its weak metabolic group were susceptible to the HPV dominant type(52,16)and HPV multiple infection.