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急性脑卒中血清神经元特异性烯醇化酶与NO的相关研究
引用本文:季海生,杨爱,陈希莲,陈永生,蒋建章.急性脑卒中血清神经元特异性烯醇化酶与NO的相关研究[J].现代检验医学杂志,2001,16(1):6-9.
作者姓名:季海生  杨爱  陈希莲  陈永生  蒋建章
作者单位:山东省临沂市人民医院,
基金项目:本课题为山东省科技发展计划(第一批)鲁科计字(1998)第159号编号981154302。
摘    要:目的 研究神经元特异性烯醇化酶(NSE)和部分细胞因子在急性脑血管病诊断、病情转归和判断预后的应用价值。方法 应用酶联免疫反应法(ELISA)动态测定急性脑血管病病人血清NSE、NO的水平、变化规律及其相互作用关系,利用直线回归分析血清NSE含量与其他细胞因子的相关性。结果 ①脑梗塞和脑出血病人血清NSE水平显著高于对照组,发病后第1d最高,随着时间的推迟逐渐下降,至发病后28d仍明显高于对照组,发病后各时间点之间比较无显著性差异。②脑梗塞和脑出血病人血清NO水平显著降低,随着时间的推迟逐渐有升高趋势,至发病后28d仍明显低于对照组。结论 NSE、NO可作为急性脑卒中早期诊断、判断病情转归和预后的综合评价指标。

关 键 词:脑梗塞  脑出血  神经元特异性烯醇化酶  一氧化氮
文章编号:1005-1716(2001)01-006-04
修稿时间:2000年8月11日

The Interrel Ationresearch Between Neuronspecific Enolase and Nitric Oxide in Serum of Patients with Acute Cerebral stroke
JI Hai sheng,YANG Ai,CHEN Xi lian,CHEN Yong sheng,JIANG Jian zhang.The Interrel Ationresearch Between Neuronspecific Enolase and Nitric Oxide in Serum of Patients with Acute Cerebral stroke[J].Journal of Modern Laboratory Medicine,2001,16(1):6-9.
Authors:JI Hai sheng  YANG Ai  CHEN Xi lian  CHEN Yong sheng  JIANG Jian zhang
Abstract:Objective To study the value of the neuron-spec ific enolase andnitric oxide in serum of patients with acute cerebral stroke and the applied of diagnosis,development and outcome in stroke.Methods The level of NSE,NO in serum of patients with acute cerebral stroke were determined by enzyme-linked immuno-sandwich assy (ΕLISA).The level of NO was determined by colorimetric method.The correlation between the NSE and the NO were analysed by linear corelation-regression.Results ①The serum level of NSE of patients with acute cerebral stroke was markly higher than that of controll group,and peaked in 1 d,then decresed for 28 d.②The serum level of NO of patients was lower than that of controll group,and increased eventually for 28d.Conclusion The NSE and NO might serve as indexes of diagnosis,development and outcome in stroke.
Keywords:Cerebral infarction  Cerebral hemorrhage  Neuron specific enolase  Nitric oxide
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