血清CYFRA21-1，CA125，CA19-9 水平联合检测在胃癌诊断中的价值

目的 探讨血清中细胞角蛋白19片段抗原21-1(cytokeratin 19 fragment antigen21-1,CYFRA21-1),糖类抗原125(carbohydrate antigen,CA125)与CA19-9联合检测在胃癌诊断中的应用价值。方法 选择2017年8月～2019年6月在西安市鄠邑区人民医院诊治的良性胃肿瘤40例(良性组)和胃癌患者90例(胃癌组),检测所有患者的血清CYFRA21-1,CA125和CA19-9水平并判定异常情况,记录联合检测的结果。结果 胃癌组的血清CYFRA21-1,CA125和CA19-9含量均显著高于良性组,差异均有统计学意义(t=8.543～26.802,均P<0.05); 胃癌组CYFRA21-1,CA125和CA19-9的异常率及三指标联合检测的异常率均显著高于良性组,差异均有统计学意义(t=4.238～12.676,均P<0.05); Spearman等级相关分析显示胃癌与CYFRA21-1,CA125,CA19-9具有显著相关性(r=0.385～0.544,均P<0.05)。ROC曲线分析显示:CYFRA21-1,CA125,CA19-9与联合检测鉴别诊断胃癌的曲线下最大面积分别为0.766,0.674,0.714和0.844。结论 血清CYFRA21-1,CA125,CA19-9在胃癌中呈现高表达,与胃癌的发生显著相关,联合检测具有较好的诊断价值。

Value of Combined Detection of Serum CYFRA21-1, CA125 and CA19-9 Levels in the Diagnosis of Gastric Cancer

Objective To investigate the values of combined detection of serum Cytokeratin 19 fragment antigen 21-1(CYFRA 21-1), carbohydrate antigen 125(CA125)and carbohydrate antigen19-9(CA19-9)in the diagnosis of gastric cancer.Method From August2017 to June 2019, 40 cases of benign gastric neoplasms(benign group)and 90 cases of gastric cancer patients(gastric cancer group)were selected and treated in Xi'an City Huyi District People's Hospital. CYFRA21-1, CA125 and CA19-9 in the serum of all patients were detected to determine the positive rates and record the effect of joint detection. Results The levels of CYFRA21-1, CA125 and CA19-9 in the serum of gastric cancer group were significantly higher than those in the benign group,the difference wasstatistically significant(t=8.543～26.802, all P<0.05). The abnormal rates of CYFRA21-1, CA125 and CA19-9 in the gastric cancer group and the combined detection of the three indicators were significantly higher than those in the benign group,the difference wasstatistically significant(t=4.238～12.676, all P<0.05).Spearman rank correlation analysis showed that gastric cancer was associated with CYFRA21-1, CA125, CA19-9(r=0.385～0.544, all P<0.05). The ROC curve analysis showed that the maximum areas under the curve of CYFRA21-1, CA125, CA19-9 and combined detection for differential diagnosis of gastric cancer were 0.766, 0.674, 0.714 and 0.844.Conclusion The levels of CYFRA21-1, CA125 and CA19-9 in the serumare highly expressed in gastric cancer, which are significantly correlated with the occurrence of gastric cancer,and the combined detection have good diagnostic values.