婴幼儿血管瘤发生发展与消退：干细胞、内皮细胞及细胞因子的参与及作用

背景：目前尚缺少对血管瘤的有效治疗，其原因在于对其发病机制的认识仍不清楚。 目的：回顾分析近年来有关血管瘤流行病学特点、病理生理特点及发病机制的文献，认识目前有关血管瘤发病机制的研究进展，为血管瘤发病机制的研究及药物治疗的研发提供线索。 方法：计算机检索PubMed数据库2009年1月至2014年2月有关血管瘤发病机制、病理生理特点及流行病学数据的研究，检索主题词分别为“hemangioma，capil ary，classification，epidemiology，etiology，embryology；cytology，physiopathology，pathology，immunology，genetics，drug therapy，therapy”。 结果与结论：血管瘤发生、发展及消退的研究已取得显著进展，但目前对血管瘤还缺少大样本、多中心的流行病学统计数据，对血管瘤发病机制尚未提出完善的学说，各学说研究对象多为某一单一因素，各因素之间的相互关系尚未明确。血管瘤发病机制研究的瓶颈在于缺少完善的动物研究模型，而现有血管瘤裸鼠研究模型存在一定限制，积极研发新的动物研究模型是血管瘤发病机制研究的关键。

Role of stem cells,endothelial cells and cytokines in the development and regression of infantile hemangioma

BACKGROUND：At present, there are few efficient therapies for infantile hemangioma, and the pathogenesis mechanisms remain unclear.
OBJECTIVE：To review the literatures available on the epidemiology, pathophysiology and pathogenesis of infantile hemangioma, to understand the research progress on the pathogenesis of infantile hemangioma, and to provide a reference for developing new drug therapies.
METHODS：A computer-based online search was performed in the PubMed database for literatures related to the pathogenesis, physiopathological features and epidemiology data of infantile hemangioma published from January 2009 to February 2014. The subject headings are“hemangioma, capil ary, classification, epidemiology, etiology, embryology, cytology, physiopathology, pathology, immunology, genetics, drug therapy, therapy”.
RESULTS AND CONCLUSION：Accumulating evidence has investigated the occurrence, development and regression of infantile hemangioma. However, no large-scale, multi-central epidemiology data are reported, and there is no theory explaining the pathogenesis of infantile hemangioma completely. Moreover, the relationship between al those theories about the pathogenesis remains unclear. The most important obstacle constraining the research is the lack of ideal animal model of infantile hemangioma. Due to the restrictions of nude mice models, it is imminent to develop new animal models for infantile hemangioma research.