力学因素对间充质干细胞成骨分化的影响

背景：随着间充质干细胞的广泛研究,间充质干细胞能够向成骨方向分化已得到充分证实。近年来,许多学者致力于研究力学因素对体外培养间充质干细胞增殖和定向诱导分化的影响。目的：综述力学因素对间充质干细胞成骨分化产生的影响。方法：应用计算机检索PubMed,Science Direct,ISI-SCIE,中国期刊全文数据库,中国期刊全文数据库_世纪期刊,中国博士学位论文全文数据库,中国优秀硕士学位论文全文数据库数据库中1999-01/2012-01关于力学因素对间充质干细胞成骨分化影响的文章,在标题和摘要中以＂力学因素,间充质干细胞,成骨分化＂或＂mechanical factors,Mesenchymal Stem Cell,Osteogenic Differentiation＂为检索词进行检索。选择文章所述内容涉及力学因素对间充质干细胞中成骨分化的作用,并且选择近期发表或发表在权威杂志文章。初检索到文献104篇,最终入选30篇文献进行综述。结果与结论：近年的各项实验都证明,力学因素对间充质干细胞的增殖和分化、形态、发育和功能起着重要的调节作用。而力学刺激的大小、方式以及作用时间对间充质干细胞定向分化的调节、功效作用不尽相同。应选择最佳的力学刺激促使间充质干细胞的成骨分化,以达到最佳的临床治疗效果。

Effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells

BACKGROUND：With wide study of mesenchymal stem cells,the osteogenic differentiation of mesenchymal stem cells has been fully confirmed.Recently,many scholars are studying the effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells.OBJECTIVE：To review the effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells.METHODS：A computer-based online retrieval of PubMed,ScienceDirect,ISI-SCIE,Chinese Journal Full-text Database,China Journal Full-text Database（Century Journals Project）,China Doctor Dissertations Full-text Database,China Master＇s Theses Full-text Database for searching papers describing the effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells published between January 1999 and December 2012 using the Key words＂mechanical factors,mesenchymal stem cell,osteogenic differentiation＂ in English and Chinese.The papers published recently or in high-impact journals were selected.A total of 104 papers were initially selected,and 30 were included in the final analysis.RESULTS AND CONCLUSION：Mechanical factors play an important role in proliferation,differentiation,morphology,development and function of mesenchymal stem cells.Mechanical stimulations at different intensities,modes and for different time produce different effects on directed differentiation and function of mesenchymal stem cells.The optimal mechanical stimulation promoted the osteogenic differentiation of mesenchymal stem cells,thereby achieving the optimal clinical therapeutic effects.