亚低温对重症脑出血手术治疗患者血清神经元特异性烯醇化酶和血糖的影响

目的研究亚低温对重症脑出血手术治疗患者血清神经元特异性烯醇化酶（NSE）和血糖的影响。方法82例重症脑出血患者随机分为治疗组和埘照组，对照组除了不进行亚低温治疗外其他治疗方法与治疗组相同，分别于治疗前和治疗第3、5、7d测外周血NES和血糖，3个月时进行GOS预后评分。结果治疗组治疗后外周血NSE和血糖与对照组比较差异有统计学意义，GOS预后评分明显优于对照组（P〈0．05）。结论亚低温能降低重症脑出血患者的血清NSE和血糖，对神经元细胞有良好的保护性作用。

Influence of mild hypothermia therapy on serum levels of blood neuron-specific enolase and glucose in the patients of severe cerebral hemorrhage

Objective To study the influence of mild hypothermia therapy on serum levels of blood neuron-specific enolase(NSE) and glucose in the patients of severe cerebral hemorrhage. Methods 82 severe cerebral hemorrhage patients were randomly assigned into the treatment group( n =41 )and the control group( n=41 ). Besides the routine treatment,mild hypothermia was used in the treatment group and their temperatures were maintained between 32℃ and 34℃ for 7 days. The control group received only routine treatment. NSE and blood glucose were measured in the two groups before the treatment and at 3rd,5 th,7th day after the treatment.Prognosis was evaluated with GOS at 3 months. Results NSE and blood glucose level in the treatment group were lower than those in the control group after the treatment, there was significant difference between the two groups. GOS of treatment group was better than that of control group at 3 months (P< 0.05 ). Conclusion Mild hypothermia is one of effective method for the treatment of the patients with severe cerebral hemorrhage. It can reduce the NSE and blood glucose levels of patients and protect neurons.