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| 阿托伐他汀对老年脑梗死伴高血脂患者颈动脉粥样硬化斑块的影响 | |
| 引用本文： | 耿桂玲,李忠梅,李以菊,常玉婷,杨延芳.阿托伐他汀对老年脑梗死伴高血脂患者颈动脉粥样硬化斑块的影响[J].中国临床实用医学,2010,4(4):117-119. |
| 作者姓名： | 耿桂玲 李忠梅 李以菊 常玉婷 杨延芳 |
| 作者单位： | 1. 山东省泰山医学院附属聊城市二院药房南区药房,252600 2. 山东省泰山医学院附属聊城市二院过敏原室,252600 3. 山东省泰山医学院附属聊城市二院生殖医学,252600 4. 山东省泰山医学院附属聊城市二院神经内科,252600 |
| 摘 要： | 目的探讨阿托伐他汀的降脂疗效及对老年脑梗死伴高血脂患者颈动脉粥样硬化斑块的影响。方法采取治疗前后自身对照比较的方法，选择50例脑梗死合并颈动脉粥样硬化斑块患者，给予阿托伐他汀10mg，qn总疗程1年，分别测定治疗前及治疗后6～12个月的血脂、颈动脉内膜-中层厚度、颈动脉斑块面积的变化。结果阿托伐他汀治疗6～12个月后，TC、LDL-C、TG降低（P〈0．05），HDL-C升高（P〈0．01）；颈动脉的内径有所扩大，颈动脉斑块缩小，尤以12个月后改变显著（P〈0．01）。结论阿托伐他汀降脂疗效确切，减少并稳定斑块的作用。 |
| 关 键 词： | 阿托伐他汀 脑梗死 高血脂 颈动脉粥样硬化斑块 |
Effect of atorvastatin on arteriosclerosis plaque of carotid artery in elder patients with cerebral infarction and hypercholesterolemia |
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| Institution: | GENG Gui-ling, LI Zhong-mei, LI Yi-ju, et al. (Department of dispensary, Liaocheng second hospital, Affiliated hospital of Taishan Medical University Shandong province, Linqing 252600, China) |
| Abstract: | Objective To investigate the effect of atorvastatin on arteriosclerosis plaque of carotid artery in elder patients with cerebral infarction and hypercholesterolemia. Methods With self-comparsion of before and after treatment,50 subjects with arteriosclerosis plaque of carotid artery were given atorvastatin 10 mg,qn for 12 months. After treatment 6 and 12 months, arteriosclerosis plaque of carotid artery、 intima-media thickness and peak index were measured in all patients. Results After 6 and 12 months adminstration of atorvastatin, TC、TG、LDL-C were all reduced (P<0.05), and HDL-C was elevated (P<0.01) in all patients.The initial diameter of carotid was significantly enlarged in 12 months (P<0.01). The size of plaque decreased (P<0.01) in 12 months after atorvastatin therapy than before(P<0.01). Conclusion The effect of atorvastatin is certain and it can stabilize the plaque of carotid artery. |
| Keywords: | Atorvastatin Cerebral infarction Hypercholesterolumia Arteriosclerosis plaque of carotid artery |
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