| 血清同型半胱氨酸浓度与冠心病相互关系的研究 |
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| 引用本文： | 牛春峰,王新春,于汉力,许红丽.血清同型半胱氨酸浓度与冠心病相互关系的研究[J].中国危重病急救医学,2001,13(3):153-155. |
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| 作者姓名： | 牛春峰 王新春 于汉力 许红丽 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院急诊科,
2. 哈尔滨锅炉厂职工医院 |
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| 基金项目： | 黑龙江省自然科学基金资助项目(No.D9706) |
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| 摘 要： | 目的探讨血清同型半胱氨酸（HCY）对冠状动脉粥样硬化性心脏病（CHD）的发生、发展、治疗及预后的影响。方法利用高效液相色谱（HPLC）法检测了30例受试对象血清中的HCY(CHD20例，正常对照组10例)。结果CHD组和对照组的血清总HCY水平分别为（16.50±7.90）μmol/L和（7.52±4.00）μmol/L，CHD患者的血清HCY水平明显高于正常对照组，有显著差异（P<0.01）。结论高同型半胱氨酸血症是CHD的独立风险因素。
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| 关 键 词： | 冠心病 同型半脱氨酸 亚甲基四氢叶酸还原酶 |
| 文章编号： | 1003-0603(2001)03-0153-03 |
| 修稿时间： | 2000年8月23日 |
The relationship between blood homocysteine and coronary atherosclerotic heart disease |
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| NIU Chunfeng,WANG Xinchun,YU Hanli,et al..The relationship between blood homocysteine and coronary atherosclerotic heart disease[J].Chinese Critical Care Medicine,2001,13(3):153-155. |
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| Authors: | NIU Chunfeng WANG Xinchun YU Hanli |
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| Institution: | NIU Chunfeng,WANG Xinchun,YU Hanli,et al. 1Emergency Department of the Second Affiliated Hospital of the Harbin Medical University,Harbin Heilongjiang 150086 |
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| Abstract: | Objective:To study the relationship between the incidence,the development,the therapy,and the prognosis of coronary atherosclerotic heart disease (CHD) and plasma homocysteine (HCY).Methods: Highperformance liquid chromatography with fluorescence detection had been utilized for the rapid determination of total HCY in serum.Thirty subjects were studied,20 of them had CHD,and the others were healthy controls.Results:The mean HCY from CHD and control group were (16.50±7.90) μmol/L and (7.52±4.00)μmol/L,respectively.The difference was significant (P<0.01).Conclusions:Hyperhomocysteinemia is an independent risk factor for CHD. |
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| Keywords: | coronary atherosclerotic heart disease homocysteine methylenetetrahydrofolate reductase |
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