Tuberculosis during lung cancer treatment-A case series |
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| Institution: | 1. Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan;2. Department of Urology, JA Mie Komono Kosei Hospital, Fukumura 75, Komono-cho, Mie-gun, Mie, 510-1234, Japan;3. Infection Control Team, JA Mie Komono Kosei Hospital, Fukumura 75, Komono-cho, Mie-gun, Mie, 510-1234, Japan;1. Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China;2. Department of Blood Transfusion, Affiliated Hospital of Zunyi Medical University, Zunyi, China;3. School of Laboratory Medicine, Zunyi Medical University, Zunyi, China;1. Department of Internal Medicine, Groupe Hospitalier Sud Ile de France, 77000, Melun, France;2. Department of Infectious Diseases, Nord Franche-Comté Hospital, 90400, Trévenans, France;3. Department of Clinical Immunopathology, Saint-Louis Hospital, University of Paris, 75010, Paris, France;1. Department of Internal Medicine, Rambam Healthcare Campus, Haifa, Israel;2. Hematology Department and Bone Marrow Transplantation Unit, Rambam Healthcare Campus, Haifa, Israel;3. Infectious Disease Institute, Rambam Healthcare Campus, Haifa, Israel;1. Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan;2. Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;3. Department of Respiratory Medicine, Nagasaki Aino Memorial Hospital, Nagasaki, Japan;4. Department of Otolaryngology-Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;5. Department of Radiology, Nagasaki University Hospital, Nagasaki, Japan;6. Department of Neurology and Strokology, Nagasaki University Hospital, Nagasaki, Japan |
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| Abstract: | This study aimed to clarify the characteristics of patients with lung cancer undergoing treatment until the onset of tuberculosis. Between 2005 and 2019, patients who were admitted to Tokyo National Hospital due to tuberculosis during lung cancer treatment were examined retrospectively. There were 42 patients, and detailed medical information was obtained in 39 patients. The median age of the 39 patients were 75 years (range: 47–92 years), of which 33 were males and 36 were Japanese Baby Boomers or older. Regarding risk factors for developing tuberculosis, smoking was noted in 34 cases, oral corticosteroid use in 13, and previous tuberculosis in six. Thirty-seven patients had one risk factor and 19 had two or more risk factors, but diagnosis of latent tuberculosis infection (LTBI) was obtained in only one patients, and none had received LTBI treatment. The first-line treatment for lung cancer was resection in 13 cases, chemoradiotherapy in 6, chemotherapy in 10, radiation therapy in 3, laser therapy in 1, and best supportive care (BSC) alone in 6. At tuberculosis onset, BSC accounted for 17 cases, but other situations were considerably existed such as anticancer medication (12 cases), and observation after lung cancer treatment (10 cases). Tuberculosis occurred in various situations in elderly patients with lung cancer. It is critical to actively evaluate the risk of tuberculosis and consider LTBI screening and treatment. |
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| Keywords: | Lung cancer Cancer therapy Tuberculosis Risk factor Latent tuberculosis infection |
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