乳腺癌超声造影特征与C-erbB-2、p53表达的相关性研究

目的 探讨乳腺癌肿块超声造影灌注特征与癌基因C-erbB-2、p53表达的相关性.方法 回顾性分析51例经手术及病理确诊的乳腺癌患者术前超声造影资料,术后对肿瘤标本采用免疫组织学方法测定C-erbB-2、p53蛋白表达情况,并分析其与超声造影特点之间的关系.结果 ①乳腺癌患者肿块C-erbB-2、p53阳性表达率分别为45.1％(23/51)和41.2％(21/51).②51例乳腺癌患者肿块的增强模式均以向心性、快速增强、高增强为主,与C-erbB-2及p53表达无关.③C-erbB-2、p53阳性表达的乳腺癌患者,肿块均出现灌注不均匀的几率增加,两者间有关联(P＜0.05),且C-erbB-2阳性表达的乳腺癌患者肿块出现灌注缺损的几率增加,与阴性表达的乳腺癌患者肿块比较差异有统计学意义(P＜0.05).④C-erbB-2、p53阳性表达的乳腺癌患者,肿块出现放射状或穿支血管的几率增加,两者间有关联(P＜0.05),尤其以后者较为显著(P＜0.01).结论 乳腺癌超声造影特征与C-erbB-2、p53阳性表达之间存在一定的相关性.乳腺癌超声造影特征能在一定程度上反映癌细胞的生物学行为及预后,可为临床选择合理的治疗方案提供参考.

Relationship between contrast-enhanced ultrasound features and expression of C-erbB-2 and p53 in breast cancer

ABSTRACT Objective To explore relationship between contrast-enhanced ultrasound features and the expression of C- erbB-2 and p53 in breast cancer. Methods The contrast-enhanced ultrasound appearances of 51 patients with breast cancer confirmed by pathology were analyzed retrospectively. Immunohistochemical method was used to detect the expression of C-erbB-2 and p53 in all the breast cancer. The relationship between contrast-enhanced ultrasound appearances and the expression of C- erbB-2 and p53 was analyzed. Results （1）The positive expression rate of C-erbB-2 and p53 in breast cancer were 45.1% （23/51 ） and 41.2% （21/51 ）, respectively. （2）The main enhanced pattern of breast cancer was central, high-speed and high-enhanced, which was not related to C-erbB-2 and p53 （/9〉0.05）. （3）The appeared rate of non-uniform perfusion increased in breast cancer with C-erbB-2 and p53 positive expression, and there was a correlation between the two（P〈0.05 ）. The appeared rate of perfusion defect increased in breast cancer with C-erbB-2 positive expression. There was a significant difference compared with breast cancer with C-erbB-2 negative expression （P〈0.05）. （4）The appeared rate of peripheral radial or perforator vessel increased in breast cancer with C-erbB-2 and p53 positive expression, and there was a correlation between the two （P〈0.05）. In particular, the latter was more significant（P〈0.01 ）. Conclusion Contrast-enhanced ultrasound features were related to the expression of C- erbB-2 and p53 in breast cancer in some extent. Contrast-enhanced ultrasound features of breast cancer can reflect the biological behavior and prognosis of breast cancer cells, which can provide a reference information for selecting reasonable therapy method in patients with breast cancer.