血管回声跟踪技术评价严格血糖控制对2型糖尿病患者颈动脉弹性的影响

目的采用血管回声跟踪（ET）技术评价严格血糖控制对2型糖尿病（T2DM）患者颈动脉弹性的影响。方法选择病程2～5年的T2DM患者68例和正常对照组54例，采用ET技术测定颈动脉弹性参数，即硬化值（β）、弹性系数（Ep）、增大指数（AI）、顺应性（AC）和单点脉搏波传导速度（PWVβ）。结果①与正常对照组比较，T2DM组β、Ep、AI和PWVβ值明显增高，而AC值降低（P〈0．05）；②T2DM组糖化血红蛋白（HbAlc）与13、Ep、AI和PWVβ呈显著正相关，与Ac呈显著负相关；③严格血糖控制的T2DM1组β、Ep、AI和PWVβ值较血糖控制不佳的T2DM2组明显降低，而AC值升高。结论严格血糖控制可明显增加T2DM患者颈动脉弹性，改善血管内皮功能。

Effect of strict glycemic control on carotid elasticity in patients with type 2 diabetes mellitus by E-tracking evaluation

Objective To evaluate the effect of strict glycemic control on the carotid elasticity in patients with type 2 diabetes mellitus （T2DM）by E - Tracking technology. Methods Sixty - eight patients in two to five years of T2DM and 54 normal subjects were enrolled in this study. The carotid artery elasticity parameters were measured by E - tracking technology, including stiffness parameters （ β ） , pressure - strain elasticity modulus （ Ep ） , arterial compliance （ AC ） , augmentation index （AI） and pulse wave velocity （PWVβ）. Results ①Compared with the control group, the value of β, Ep, AI and PWVβ in T2DM group was increased, while the value of AC was decreased （P 〈 0.05 ）. ② HbAlc in T2DM group showed a positive correlation with β, Ep, AI, PWVβ, while a negative correlation with AC. ③Compared with T2DM group with poor glycemic control, the value of β, Ep, AI and PWVβ was decreased in T2DM group with strict glycemic control, while AC was increased. （P 〈 0. 05 ）. Conclusion Strict glyeemie control can obviously increase carotid artery elasticity and improve endothelial function.