三阴性乳腺癌中VEGF-C表达与淋巴管密度的相关性研究

目的 研究三阴性(雌激素受体、孕激素受体、人表皮生长因子受体2均阴性)乳腺癌淋巴管内皮生长因子(VEGF-C)表达情况和与淋巴管密度的关系.方法 105例乳腺癌标本.其中三阴性乳腺癌42例,非三阴性乳腺癌标本63例,应用免疫组化方法检测标本的VEGF-C表达情况及应用D2-40标记检测淋巴管密度.结果 VEGF-C在三阴性乳腺癌高表达64.2%,与淋巴结有无转移、淋巴管密度、肿瘤大小、临床分期相关(P<0.05),而与年龄、病理类型无关(P<0.05);VEGF-C在三阴性和非三阴性乳腺癌表达分别为64.2%和33.3%,差异有显著性(P<0.05).结论 VEGF-C在三阴性乳腺癌中高表达与淋巴管生成和肿瘤演进相关.

Study on relationship between expression of VEGF-C and lymphatic density in triple negative breast cancer.

Objective To study the relationship between expression of VEGF - C and lymphatic density in triple negative （ negative in es- trogen receptor, gestodene receptor and human epithelial growth factor receptor） breast cancer. Methods One hundred and five breast cancer samples including 42 triple negative breast cancer samples and 63 non - triple negative breast cancer samples in this hospital during January 2009 to December 2009 were selected for this study. The expression of VEGF - C was examined by immunohistochemical method, and labelling with D2 -40 was applied for examination of density of lymphatics. Results The expression of VEGF - C in triple negative breast cancer was high （64. 2% ）, and it was positively correlated with lymph node metastasis, size of tumor, TNM staging and lymphatic density, hut it was negatively corre- lated with age and pathological types. The expressions of VEGF - C in triple negative breast cancer and non - triple negative breast cancer were 64.2% and 33.3 % respectively, and their difference was significant （ P 〈 0.05 ）. Condnslon The expression of VEGF - C in triple negative breast cancer is high, and it is correlated with lymphangiogenesis and progress of tumor.