血清组织多肽特异性抗原表达水平在乳腺癌中的临床应用价值探讨

目的分析血清组织多肽特异性抗原(TPS)水平与乳腺癌生物学行为的相关性,探讨血清TPS表达在乳腺癌中的临床应用价值。方法回顾性选取2019年1月至2020年1月在首都医科大学附属北京天坛医院住院治疗的乳腺癌患者85例为乳腺癌组;选取同时期诊断为乳腺良性肿瘤的患者83例为良性疾病组;选取同时期健康体检者86例为健康对照组。应用酶联免疫吸附实验(ELISA)法检测所有入选对象的血清TPS表达水平,分析比较血清TPS的表达情况与是否发生淋巴结转移、TNM分期、病理学分化程度、雌、孕激素受体及Cer Bb-2基因等的关系,同时检测TPS与肿瘤标志物CEA、CA15-3、CA125联合检测在乳腺癌诊断中的灵敏度及特异度情况。结果乳腺癌组患者TPS表达水平及阳性率显著高于良性疾病组和健康对照组(P <0.05),乳腺癌患者经治疗后血清TPS表达水平明显降低,与治疗前比较差异有统计学意义(P <0.05);乳腺癌患者血清TPS表达与年龄、肿瘤直径无关(P> 0.05),与临床TNM分期、腋窝淋巴结转移、肿瘤分化程度密切相关(P <0.05)。TPS联合CEA、CA15-3和CA125检测可大幅度提高乳腺癌诊断的灵敏度和特异度,与单独使用TPS指标相比差异具有统计学意义(P <0.05)。结论血清TPS的表达水平与乳腺癌患者生物学行为存在相关性,其可作为乳腺癌早期诊断、治疗效果评价、复发转移及预后判断的临床指标,为乳腺癌患者的临床治疗及预后判断提供有力的依据和新思路。

Clinical value of serum tissue polypeptide specific antigen level in breast cancer

Objective To analyze the correlation between serum TPS level andbiological behavior of breast cancer,and to explore the clinical value of serumTPS expression in breast cancer.Methods A tatol of 85 breast cancer patients in Beijing Tiantan Hospital,Capital Medical University from January 2019 to January 2020 were selected as breast cancer group;83 patients with benign breast tumor diagnosed were selected as the benign disease group;86 patients with health examination were selected as the healthy control group.The expression of TPS in serum was detected by ELISA in all selected subjects.The relationship between the expression of TPS and lymph node metastasis,TNM stage,pathological differentiation,estrogen and progesterone receptor and CerbB-2 gene was analyzed and compared.The sensitivity and characteristics of combined detection of TPS,CEA,CA15-3 and CA125 in the diagnosis of breast cancer were also observed.Results The expression level and positive rate of TPS in breast cancer patients were significantly higher than those in benign disease group and healthy control group(P<0.05).The serum TPS level of breast cancer patients was significantly lower after treatment,which was different from that before treatment(P<0.05).The expression of TPS in cancer patients was not correlated with age and tumor size(P>0.05),and was closely related to clinical TNM stage,axillary lymph node metastasis and tumor differentiation(P<0.05).The detection of TPS combined with CEA,CA15-3 and CA125 can greatly improve the sensitivity and specificity of breast cancer diagnosis.The difference was statistically significant compared with the TPS index alone(P<0.05).Conclusion The expression of serum TPS is related to the biological behavior of breast cancer patients.It can be used as a clinical indicator for early diagnosis,treatment effect,recurrence and metastasis and prognosis of breast cancer,and provides a powerful basis and new ideas for clinical treatment and prognosis judgment of breast cancer patients.