| 血清可溶性B7-H3在原发性胆汁性胆管炎患者中的表达水平及临床预后评价 |
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| 引用本文： | 吕心路,曹磊,顾洁,陆敏丹,项晓丽,张志成,成翠娥,陆芬英,蒋廷旺.血清可溶性B7-H3在原发性胆汁性胆管炎患者中的表达水平及临床预后评价[J].临床检验杂志,2022(1):19-22. |
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| 作者姓名： | 吕心路 曹磊 顾洁 陆敏丹 项晓丽 张志成 成翠娥 陆芬英 蒋廷旺 |
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| 作者单位： | 太仓市第一人民医院检验科;苏州大学附属第一医院临床免疫研究所;常熟市第二人民医院重点专科实验室;常熟市第二人民医院眼科;常熟市第二人民医院消化科;常熟市医学检验所 |
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| 基金项目： | 姑苏卫生重点人才项目(GSWS2020106);常熟市科技发展计划(CS202016);苏州市临床重点病种项目(LCZX202125);太仓市医疗卫生应用基础研究(TC2018JCYL01) |
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| 摘 要： | 目的 探讨血清可溶性B7-H3(sB7-H3)在原发性胆汁性胆管炎(PBC)患者中的表达水平和临床预后评价.方法 选取初诊诊断为PBC的患者37例、体检健康者50例,并收集基本临床资料.用ELISA法测定血清sB7-H3及白细胞介素6(IL-6)的浓度;用全自动生化分析仪测定丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移...
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| 关 键 词： | 可溶性B7-H3 白细胞介素6 原发性胆汁性胆管炎 |
Expression levels and clinical prognosis evaluation of serum soluble B7-H3 in patients with primary biliary cholangitis |
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| LüXinlu,CAO Lei,GU Jie,LU Mindan,XIANG Xiaoli,ZHANG Zhicheng,CHENG Cuie,LU Fenying,JIANG Tingwang.Expression levels and clinical prognosis evaluation of serum soluble B7-H3 in patients with primary biliary cholangitis[J].Chinese Journal of Clinical Laboratory Science,2022(1):19-22. |
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| Authors: | LüXinlu CAO Lei GU Jie LU Mindan XIANG Xiaoli ZHANG Zhicheng CHENG Cuie LU Fenying JIANG Tingwang |
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| Institution: | (Department of Laboratory Medicine,the First People′s Hospital of Taicang,Taicang 215400,Jiangsu;Institute of Clinical Immunology,the First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu;Department of Key Laboratory,No.2 People′s Hospital of Changshu,Changshu 215500,Jiangsu;Department of Ophthalmology,No.2 People′s Hospital of Changshu,Changshu 215500,Jiangsu;Department of Gastroenterology,No.2 People′s Hospital of Changshu,Changshu 215500,Jiangsu;In stitute of Laboratory Medicine of Changshu,Changshu 215501,Jiangsu,China) |
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| Abstract: | Objective To investigate the expression levels of soluble B7-H3(sB7-H3)in serum of patients with primary biliary cholangitis(PBC)and its clinical significance.Methods The basic clinical data from 37 patients with PBC and 50 healthy controls were collected.The levels of serum sB7-H3 and interleukin 6(IL-6)were detected by ELISA.The indexes such as alanine aminotrans-ferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),γ-glutamyltransferase(GGT)and total bilirubin(T-Bil)were detected by an automatic biochemical analyzer.Meanwhile,autoantibodies were determined by the multiple bead flow cy-tometry and immunoblotting.The correlations of sB7-H3 with IL-6 and liver function indexes were analyzed by Spearman correlation a-nalysis.Results Serum sB7-H3 and IL-6 levels in PBC patients were significantly higher than that in healthy controls(P<0.0001 and P=0.0055).The levels of sB7-H3 in PBC patients with high Mayo score were significantly higher than that with low Mayo score(P=0.0006).The levels of sB7-H3 in PBC patients with positive anti-GP210 antibodies were significantly higher than that with negative antibodies(P=0.0015).Spearman correlation analysis showed that serum sB7-H3 and IL-6 levels were positively correlated with ser-um ALT,AST,ALP and T-Bil levels(P<0.05).Conclusion Serum sB7-H3 levels in PBC patients increase significantly,indicating that it has potential application value in the prognosis evaluation of PBC patients. |
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| Keywords: | soluble B7-H3 interleukin 6 primary biliary cholangitis |
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