| 急性、非急性冠状动脉病变患者血浆氧化低密度脂蛋白的变化 |
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| 引用本文： | 孟扬,汪俊军,韩爱忠,张春妮.急性、非急性冠状动脉病变患者血浆氧化低密度脂蛋白的变化[J].临床检验杂志,2009(1). |
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| 作者姓名： | 孟扬 汪俊军 韩爱忠 张春妮 |
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| 作者单位： | 南京师范大学生命科学院;南京军区南京总医院检验科; |
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| 基金项目： | 国家自然科学基金资助项目(30872411) |
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| 摘 要： | 目的探讨冠心病患者氧化型低密度脂蛋白(ox-LDL)的变化及机制,评估ox-LDL水平检测的临床价值。方法采用ELISA法测定139例冠心病组患者急性冠状动脉综合征(ACS)76例,非ACS组63例]和100例健康对照组人群血浆ox-LDL水平;根据冠状动脉造影结果将冠心病组分为多支病变组、双支病变组和单支病变组进行比较分析。结果ACS组患者和非ACS组患者ox-LDL水平均显著高于健康对照组ACS:(188.01±69.88)μg/ml,非ACS:(137.88±59.74)μg/ml,对照组:(82.68±29.06)μg/ml;P均<0.001];且ACS组患者ox-LDL水平显著高于非ACS组患者(P<0.001)。冠状动脉多支、双支、单支病变组间ox-LDL水平不同(183.63±79.42)μg/ml,(164.15±63.79)μg/ml和(146.97±58.40)μg/ml,P<0.05],多支高于单支(P<0.01)。多因素分析显示冠状动脉病变程度仅与ox-LDL相关(R2=0.048,β=0.217,P=0.000)。结论冠心病患者ox-LDL水平升高,与病变程度相关,急性冠脉综合...
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| 关 键 词： | 氧化低密度脂蛋白 急性冠状动脉综合征 冠状动脉造影 |
Changes of serum oxidized low-density lipoprotein in patients with acute and non-acute coronary artery disease |
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| MENG Yang,WANG Jun-jun,HAN Ai-zhong,ZHANG Chun-ni.Changes of serum oxidized low-density lipoprotein in patients with acute and non-acute coronary artery disease[J].Chinese Journal of Clinical Laboratory Science,2009(1). |
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| Authors: | MENG Yang WANG Jun-jun HAN Ai-zhong ZHANG Chun-ni |
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| Institution: | 1.Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology;Life Science College;Nanjing Normal University;Jiangsu;Nanjing210046;2.Department of Medical Laboratory Science;Nanjing General Hospital;Nanjing Military Command;PLA;Nanjing 210002;China |
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| Abstract: | Objective To explore the changed mechanism of plasma oxidized low-density lipoprotein(ox-LDL)in the patients with coronary heart disease,and to evaluate the clinical value of detection for ox-LDL level.Methods Enzyme-linked immunosorbent assay(ELISA)was used to measure the plasma ox-LDL in 139 patients with coronary heart disease,among them 76 were acute coronary syndrome(ACS)and 63 were non-ACS patients,and in 100 healthy controls.The patients were divided by coronary angiography into multi-vessel disease ... |
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| Keywords: | oxidized low-density lipoprotein acute coronary syndrome coronary angiography |
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