护理干预对接受α-干扰素治疗患者焦虑、抑郁发生率的影响

目的探讨降低干扰素所致焦虑、抑郁发生率的有效护理干预措施，使乙型肝炎患者顺利完成干扰素治疗。方法选择220例接受α-干扰素治疗的乙型肝炎患者，随机分为干预组115例和对照组105例。对照组采用常规护理，干预组在此基础上运用密切观察、心理干预、对症处理等综合干预方法。采用Zung抑郁自评量表比较2组焦虑、抑郁发生率及患者的治疗完成情况。结果治疗3、6、12个月后，干预组焦虑、抑郁发生率显著低于对照组（P〈0．05）。干预组112例完成全程治疗，对照组72例完成全程治疗，全程治疗率干预组显著高于对照组（P〈0．01）。结论密切观察、心理干预、对症处理等护理干预措施可有效降低α-干扰素所致焦虑、抑郁的发生率。

Influence of nursing intervention on anxiety and depression of patients receivingα-interferon treatment

Objective To discuss effective nursing measures to reduce incidence rate of anxiety and depression caused by α-interferon treatment and to enable the successful completion of interferon treatment for hepatitis B patients. Methods Hepatitis B patients（220 cases） receiving α-interferon treatment were randomly divided into the intervention group（ 115 cases） and the control group（ 105 cases）. The control group adopted conventional nursing,while in the intervention group,comprehensive intervention measures such as close observation,psychological intervention,symptomatic treatment intervention were used. Zung self-rating depression scale （SDS） was used to compare the incidence rate of anxiety and depression. The completion of treatment was also compared between the two groups. Results After 3,6 and 12 months of treatment incidence rate of anxiety and depression in the intervention group was significantly lower than that of the control group （P 〈 0.05）.There were 112 cases completed treatment in the intervention group,which were higher than those of the control group, 72 cases （P 〈 0.01 ）. Conclusions Nursing intervention measures such as close observation, psychological intervention, symptomatic treatment can reduce incidence rate of anxiety and depression caused by α-interferon treatment.