危重病患儿心肌损伤的临床研究

目的通过测定危重病患儿血清心肌肌钙蛋白I（cTnI）和心功能指标，探讨危重病患儿心肌损伤的发生率及其心功能的变化。方法对38例危重病患儿采用ELISA法测定外周血中cTnI含量，同时测定射血分数（EF）、心短轴缩短率（FS）、主动脉峰值流速（PFVA）、肺动脉峰值流速（PFVP），并分析cTnI与心功能的关系。34例健康体检儿童作为正常对照组。结果危重病患儿cTnI测定值显著高于正常对照组（P〈0．01），心功能指标显著低于正常对照组（P〈0．01）。cTnI与EF、FS、PFVA、PFVP呈直线负相关。结论通过检测外周血cTnI含量，能早期诊断心肌损伤、心功能下降的发生，从而得到早期治疗，改善预后。

Study on the myocardial injury of critical child patients

Objective To study the incidence of myocardial injury and variation of cardiac function of critical child patients by detecting cardiac troponin I （cTnI） in blood and cardiac function indexde. Methods ELISA was used to detect the eTnI in blood of 38 critical child patients, in the meantime, EF, FS, PFVA, and PEVP were measured too. The correlation between cTnI and cardiac function was analyzed. The control group was consisted of 34 healthy children. Results The cTnI in blood of critical child patients was conspicuously higher than that of the control group （ P 〈 0. 001 ）, and cardiac function was yet rather lower （ P 〈 O. OI ）. EF, FS, PFVA, PFVP, all had a linear negative correlation with cTnI in blood. Conclusion By detecting the eTnI in blood, we could have an early diagnosis of myocardial injury and the deterioration of cardiac function for an early - stage treatment and improving prognosis.