CPAP治疗对2型糖尿病合并OSAHS患者血糖及生活质量的影响

目的评价持续气道正压通气治疗对2型糖尿病(T2DM)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血糖及生活质量的影响。方法选择2014年1-12月我院收治的2型糖尿病合并OSAHS患者60例,随机分为干预组和对照组。对照组给予2型糖尿病的常规治疗及OSAHS的一般治疗,干预组患者在此基础上同时使用持续气道正压通气呼吸机治疗。比较两组治疗前后呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSpO2)、空腹血糖(FPG)、餐后2h血糖(PPG)、糖化血红蛋白(HbA1c)及Calgary生活质量指数(SAQLI)。结果3个月后,干预组AHI、LSpO2及SAQLI总分较对照组高,FPG、PPG及HbA1c较对照组低,差异均有统计学意义(P0.05)。结论持续气道正压通气治疗T2DM合并OSAHS患者可以改善睡眠呼吸情况,有效降低血糖,提高生活质量。

Effect of CPAP on blood glucose and life quality for patients with type 2 diabetes mellitus combined with OSAHS

Objective To evaluate the effect on blood glucose and the quality of life by continuous positive airway pressure (CPAP) treatment on patients with type 2 diabetes mellitus(T2DM) combined with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Sixty patients diagnosed as T2DM and OSAHS from January 2014 to December 2014 were randomly divided into the intervention group and control group.Patients in control group was given basic treatment,including conventional treatment of type 2 diabetes and OSAHS's general treatment.Patients in intervention group were treated with CPAP for 3 months.The apnea hypopnea index (AHI),lowest SpO2 (LSpO2),fasting plasma glucose (FPG),postprandial blood glucose (PPG),hemoglobin A1c(HbA1c) and the sleep apnea quality of life index(SAQLI) was measured and compared for the two group before and after treatment.Results After 3 months intervention,the AHI,LSpO2 and the total score of SAQLI for patients in intervention group was higher than that of the control group.The FPG,PPG and HbAlc was lower than that of the control group.There was significant difference between the two groups(P ＜ 0.05).Conclusion CPAP can improve the sleep respiratory conditions,reduce blood glucose and improve the quality of life in patients with T2DM and OASHS.