尼卡地平和拉贝洛尔对妊娠高血压危象控制有效性临床研究

摘要]目的：观察比较静脉使用尼卡地平和拉贝洛尔对妊娠高血压危象有效性控制。方法：妊娠高血压危象58例分为两组，A组（28例）使用尼卡地平注射液，以0．5～5μg／（kg·min）速度静脉泵人；B组（30例）使用拉贝洛尔以0．25～2mg／min静脉泵人，两组同时常规使用硫酸镁预防子痫发生，在此期间观察血压心率变化。结果：A组用药4h、24h后安全达标率为96％、48h后目标血压达标率为93％，平均血压为（105±9.1）mmHg（1mmHg=0．133kPa），11例需联合降压治疗。B组用药4h、24h后安全达标率为90％，48h后目标血压达标率分别为73％，平均血压为（118±10．0）mmHg，23例需联合降压治疗，3例换尼卡地平静脉控制。两组在48h降压疗效差异有统计学意义（P〈O．05）。两组用药前后心率变化无统计学意义。结论：尼卡地平治疗妊娠期高血压危象在降压4h、24h疗效与拉贝洛尔疗效相似，48h控制血压疗效优于拉贝洛尔组，未见有严重不良反应。

Clinical studies on effectiveness of nicardipine and labetalol on pregnancy-induced hypertensive crisis control

Objective：To observe and compare the effective control of using intravenous Nicardipine and Labetalol for pregnancy-induced hypertensive crisis.Method：Pregnancy-induced hypertensive crisis were divided into two groups.Group A（28cases）of hypertensive emergencies in pregnancy were treated with Nicardipine by the micro pump intravenous infusion with speed of（0.5~5）ug/kg/min group B（30cases）were treated with Labetalol by the micro pump intravenous infusion with speed of（0.25~2）/min at the same time,Magnesium sulfate was used to prevent eclampsia seizures in two groups.During this time,we should keep monitoring the blood pressure and EKG changes.Result：In A group the target levels of blood pressure rate was 93% at 4hours＇ and 24hours＇ after medication.48hours＇ average blood pressure was（105±9.1）mmHg（1mmHg=0.133KPa）.11 patients required combination with other antihypertensive drugs.Group B the target levels blood pressure rate was90%at 4hand 24 hafter medication.The target blood pressure rate was 73%at 48 hafter medication.48hours＇ average blood pressure was（118±10.0）mmHg（1mmHg=0.133KPa）,23 patients required combination with other antihypertensive drugs,3cases of changing intravenous Nicadipine control.There was a significant difference in antihypertensive effects between the two groups at 48 hafter medication（P0.05）.There was no statistic difference in change of heart rate before and after treatment in two groups.Conclusion：Nicadipine therapy in severe pregnancy induced hypertension is similar to Labetalol at 4hand 24 hafter medication,while is more effective at48 hafter medication.