急性脑梗死患者血栓弹力图与常规凝血试验相关性分析

目的探讨血栓弹力图(TEG)各参数与常规凝血试验各指标间的相关性,评价2种方法在检测急性脑梗死患者凝血状况中的共性和差异性。方法选择107例急性脑梗死患者,所有患者住院期间均进行TEG检测,并同时与常规凝血试验做同步测定。结果显示急性脑梗死患者的反应时间(R值)和凝血酶形成时间(K值)较对照组明显缩短,血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)检测指标偏低,且TEG检测的多项参数与常规凝血试验指标存在相关性。TEG参数中R值和K值与PT-国际标准化比率(PT-INR)呈正相关,与纤维蛋白原(FIB)水平呈负相关。α角和血栓最大弹力度(MA值)与PT-INR呈负相关,与FIB水平呈正相关。结论 TEG检测参数不仅能较全面地反映体内的凝血变化过程,而且与急性脑梗死患者的常规凝血试验指标间的水平存在相关性,与常规凝血试验同时检测,可起到互补作用。

The correlation analysis the thromboelastogram and conventional coagulation tests in patients with acute cerebral infarction

Objective To investigate the correlations between the thromboelastogram（TEG） and conventional coagulation tests in patients with acute cerebral infarction,and evaluate the 2 methods＇ commonness and differences in determining the blood coagulation of acute cerebral infarction.Methods A total of 107 patients with acute cerebral infarction were enrolled,and all patients were determined by TEG and conventional coagulation tests simultaneously.Results The reaction time（R） and prothrombin formation time（K） in the dead patients with acute cerebral infarction were significantly shorter than those in the controls,and the results of prothrombin time（PT） and activated partial thromboplastin time（APTT） were low.There were correlations between the TEG and conventional coagulation tests.The R and K times of TEG parameters were positively correlated with the prothrombin time-international normalized ratio（PT-INR）,and were negatively correlated with fibrinogen（FIB）.α angle and maximal amplitude（MA） were negatively correlated with the PT-INR,and were positively correlated with FIB.Conclusions TEG parameters not only can reflect more fully in the body＇s blood clotting process,but also have correlations with conventional coagulation tests in patients with acute cerebral infarction.TEG and conventional coagulation tests can be conducted simultaneously and have mutual complementary effect.