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| 三亚地区妇女人乳头瘤病毒感染的分子流行病学调查 | |
| 引用本文： | 王玉丰,林玲,刘春雨,刘斌,李志霞,李强.三亚地区妇女人乳头瘤病毒感染的分子流行病学调查[J].检验医学,2012,27(8):628-630. |
| 作者姓名： | 王玉丰 林玲 刘春雨 刘斌 李志霞 李强 |
| 作者单位： | 1. 海南省第三人民医院检验科,海南,三亚,572000 2. 海南省第三人民医院科教科,海南,三亚,572000 3. 三亚市人民医院检验科,海南,三亚,572000 |
| 摘 要： | 目的分析三亚地区妇女人乳头瘤病毒(HPV)的感染状况以及病毒亚型在人群中的分布情况。方法采用核酸分子快速导流杂交技术,对2009年2月至2011年4月在三亚地区医院妇产科门诊就诊的2 302例妇女进行生殖道21种HPV基因型的筛查。结果 2 302例妇女中共检出HPV阳性562例,阳性率为24.41%,其中≤20岁年龄组HPV阳性率最高(36.00%),阳性率随年龄增加呈下降趋势。多重感染比例为58.54%,以二重感染最多见。HPV基因型检出率由高到低依次为:HPV16(21.06%)、HPV6(14.16%)、HPV58(13.02%)、HPV18(9.63%)、HPV52(9.29%)、HPV11(6.80%)、HPV31(6.34%)、HPVCP8304(5.21%)、HPV42(3.06%)、HPV53(2.04%)、HPV51(1.70%)、HPV66(1.70%)、HPV68(1.02%)、HPV33(0.91%)、HPV39(0.68%)、HPV44(0.68%)、HPV35(0.57%)、HPV45(0.57%)、HPV56(0.57%)、HPV43(0.57%)、HPV59(0.45%)。结论三亚地区妇女HPV感染率及多重感染率均较高,HPV常见高危型别依次为16、58、18、52和31型,分布具有一定区域性。 |
| 关 键 词： | 人乳头瘤病毒 宫颈肿瘤 流行病学 |
An epidemiological research on human papillomavirus infection among women in Sanya area |
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| WANG Yufeng , LIN Ling , LIU Chunyu , LIU Bin , LI Zhixia , LI Qiang.An epidemiological research on human papillomavirus infection among women in Sanya area[J].Laboratory Medicine,2012,27(8):628-630. | |
| Authors: | WANG Yufeng LIN Ling LIU Chunyu LIU Bin LI Zhixia LI Qiang |
| Institution: | 1.Department of Clinical Laboratory,the Third People′s Hospital of Hainan Province,Hainan Sanya 572000,China;2.Department of Scientific Education,the Third People′s Hospital of Hainan Province,Hainan Sanya 572000,China;3.Department of Clinical Laboratory,People′s Hospital of Sanya City,Hainan Sanya 572000,China) |
| Abstract: | Objective To study the status of infection and the genotype distribution of human papillomavirus（HPV） among women in Sanya area.Methods A total of 2 302 outpatient women in Sanya area from February 2009 to April 2011 were enrolled and determined for 21 HPV genotypes by DNA flow-through hybridization technique.Results Among 2 302 cases,562 cases were HPV positive,and the total positive rate was 24.41%.The highest infection rate（36.00%） was found in the age group of ≤20 years old,and the positive rate of HPV decreased with age.The total multiple infection rate was 58.54%.Among them,the double infection was common.The detection rate of detecting HPV genotypes were HPV16（21.06%）,HPV6（14.16%）,HPV58（13.02%）,HPV18（9.63%）,HPV52（9.29%）,HPV11（6.80%）,HPV31（6.34%）,HPVCP8304（5.21%）,HPV42（3.06%）,HPV53（2.04%）,HPV51（1.70%）,HPV66（1.70%）,HPV68（1.02%）,HPV33（0.91%）,HPV39（0.68%）,HPV44（0.68%）,HPV35（0.57%）,HPV45（0.57%）,HPV56（0.57%）,HPV43（0.57%） and HPV59（0.45%）.Conclusions The prevalence of HPV infection and multiple infection are common in Sanya area.The most common high-risk genotypes are HPV 16,58,18,52 and 31.The distributions have their own area character. |
| Keywords: | Human papillomavirus Cervical tumor Epidemiology |
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