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Ang-2和Tie-2在肝癌中表达及血管生成关系的研究
引用本文:李金明,谢南,黄义华,温丽丽.Ang-2和Tie-2在肝癌中表达及血管生成关系的研究[J].检验医学,2011,26(3):150-152.
作者姓名:李金明  谢南  黄义华  温丽丽
作者单位:南昌市第九医院,江西,南昌,330003
摘    要:目的流式细胞术检测血管生成素2(Ang-2)及酪氨酸激酶受体2(Tie-2)在肝癌中的表达,探讨其与CD105标记的血管表达量的关系,以期为研究肝癌发生、发展及血管生成提供理论支持。方法以112例肝细胞癌标本为研究对象,60例癌旁组织、60例正常肝组织作为对照,应用流式细胞术分别检测Ang-2、Tie-2和CD105的表达,分析其在不同临床病理特征之间的意义及相互关系。结果 Ang-2、Tie-2和CD105在肝癌中的表达均明显高于癌旁组织和正常肝组织,Ang-2、Tie-2和CD105在不同肿瘤直径、不同临床分期、不同甲胎蛋白(AFP)值及有无转移患者中比较,差异有统计学意义,肝癌中Ang-2、Tie-2和CD105的表达呈正相关。结论 Ang-2和Tie-2与肝癌的发生、发展有密切关系,Ang-2和Tie-2参与CD105表达的血管生成,联合检测Ang-2、Tie-2和CD105可能有助于肝癌患者预后判断。

关 键 词:血管生成素2  酪氨酸激酶受体2  CD105  肝癌  血管生成  流式细胞术TheexpressionsandangiogenesisstudyofAng-2andTie-2inhepatocellularcarcinomaLIJinming  XIENan  HUANGYihua  WENLili.(TheNinthHospitalofNanchangCity  JiangxiNanchang330003  China)

The expressions and angiogenesis study of Ang-2 and Tie-2 in hepatocellular carcinoma
LI Jinming,XIE Nan,HUANG Yihua,WEN Lili.The expressions and angiogenesis study of Ang-2 and Tie-2 in hepatocellular carcinoma[J].Laboratory Medicine,2011,26(3):150-152.
Authors:LI Jinming  XIE Nan  HUANG Yihua  WEN Lili
Institution:.(The Ninth Hospital of Nanchang City,Jiangxi Nanchang 330003,China)
Abstract:Objective To investigate the expressions of angiopoietin-2(Ang-2) and tyrosine kinase receptor-2(Tie-2) in hepatocellular carcinoma by flow cytometry,and investigate the relationship with CD105 in pathogenesis,development and angiogenesis.Methods 112 samples of hepatocellular carcinoma tissue were enrolled as experimental group.60 samples of tumor-adjacent tissues and 60 samples of normal hepatic tissues were enrolled as control group.The expressions and relationship of Ang-2,Tie-2 and CD105 were analyzed in different pathological character by flow cytometry.Results The expressions of Ang-2,Tie-2 and CD105 were obviously higher in the experimental group than in tumor-adjacent tissue and normal hepatic tissue.The expressions of Ang-2,Tie-2 and CD105 were associated with diameter,clinical stage,alpha fetoprotein(AFP) value and metastasis.There was positive correlationship between Ang-2 and Tie-2,Ang-2 and CD105,Tie-2 and CD105 in hepatocellular carcinoma group.Conclusions Ang-2 and Tie-2 may promote the pathogenesis and development of hepatocellular carcinoma.Ang-2 and Tie-2 may induce the angiogenesis which expresses CD105 in neoplasm.The combined determination of Ang-2,Tie-2 and CD105 may be helpful for the diagnosis and prognosis of hepatocellular carcinoma.
Keywords:CD105
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