白细胞介素及高敏C反应蛋白与原发性闭角型青光眼的相关性

目的探讨白细胞介素(IL)-1、IL-2、IL-6、IL-8、IL-10及高敏C反应蛋白(hs-CRP)水平在原发性闭角型青光眼(PACG)中的临床价值。方法选取PACG患者72例,以55名体检健康者作为正常对照组。收集所有对象的一般资料和眼部参数眼压、中央角膜厚度(CCT)、垂直杯盘比(VCDR)、眼轴长度(AL)、前房深度(ACD)、平均视野缺损(MD)、平均视敏度(MS)]。采用二分类Logistic回归分析评估PACG发生的危险因素。采用Spearman相关分析评估IL水平与PACG患者眼部参数的相关性。结果 PACG患者血清IL-6、IL-8和hs-CRP水平高于正常对照者(P<0.05),IL-1、IL-2、IL-10 2个组之间差异均无统计学意义(P>0.05)。Spearman相关分析结果显示,血清IL-6与MD、VCDR呈正相关(r值分别为0.431、0.270,P<0.05);血清IL-8与MD、VCDR呈正相关(r值分别为0.322、0.330,P<0.05),与CCT呈负相关(r=-0.279,P=0.023)。多因素二分类Logistic回归分析结果显示,IL-6和IL-8是PACG发生的危险因素比值比(OR)值分别为1.296、1.106,95%可信区间(CI)分别为1.009~1.664、1.044~1.172]。结论 IL-6、IL-8、hs-CRP可能与PACG有一定的关系。

Correlation between interleukin and high-sensitivity C-reactive protein with primary angle-closure glaucoma

Objective To investigate the clinical roles of interleukin(IL)-1,IL-2,IL-6,IL-8,IL-10 and high-sensitivity C-reactive protein(hs-CRP)levels in primary angle-closure glaucoma(PACG).Methods A total of 72 patients with PACG and 55 healthy subjects were enolled.General information and eye parametersintraocular pressure,central corneal thickness(CCT),vertical cup-disc ratio(VCDR),axial length(AL),anterior chamber depth(ACD),visual field mean deviation(MD)and visual field mean sensitivity(MS)]were collected and recorded in detail.Binary Logistic regression analysis was used to assess the risk factors of PACG.Spearman correlation analysis was used to assess the relationship between IL and eye parameters.Results The levels of IL-6,IL-8 and hs-CRP in PACG group were higher than those in control group(P<0.05).There was no statistical significance in IL-1,IL-2 and IL-10 between PACG and control groups(P>0.05).There was a positive correlation of IL-6 level with MD and VCDR in PACG patients(r=0.431 and 0.270,P<0.05).There was a negative correlation between CCT and IL-8(r=-0.279,P=0.023),and there were positive correlations of IL-8 with MD and VCDR(r=0.322 and 0.330,P<0.05).Multivariate binary Logistic regression analysis showed that IL-6odds ratio(OR)=1.296,95%confidence interval(CI)1.009-1.664]and IL-8(OR=1.106,95%CI 1.044-1.172)were correlated with PACG.Conclusions IL-6,IL-8 and hs-CRP may be related to PACG.