脑白质疏松与认知功能的关系研究

目的:评估脑白质疏松(LA)与认知功能的关系。方法:253例患者依据有无LA表现分为LA组127例和对照组126例,LA组根据年龄相关白质变化分级量表(ARWMCRs)评分又分为轻度亚组36例、中度亚组48例、重度亚组43例。应用简明精神状态量表(MMSE)和蒙特利尔认知评估量表北京版(MoCA)评估患者认知功能。结果:LA组与对照组相比,患有高血压、糖尿病的比例升高,差异有统计学意义(P<0.05)。中、重度亚组与对照组相比,MMSE和MoCA评分显著降低,差异有统计学意义(P<0.05)。LA组与对照组相比,在视空间与执行、命名能力、注意力、语言能力、抽象能力、延迟记忆能力、定向力7个认知域的评分差异均有统计学意义(P<0.05)。ARWMCRs评分与MMSE、MoCA评分呈负相关(P<0.01)。结论:LA与老年患者认知功能密切相关。

Correlation between Leukoaraiosis and Cognitive Function

Objective:To explore the correlation between cognitive impairment and leukoaraiosis(LA) in old patients.Methods:According to LA performance,253 consecutive patients were divided into 2 groups:patients with leukoaraiosis(LA group=127) and patients without leukoaraiosis(control group=126).According to results of Age-related White Matter Changes Rating Scale(ARWMCRs),the LA group was further divided into mild,moderate and severe subgroups.Mini mental state examination(MMSE) and Montreal cognitive assessment(MoCA) were used to assess the cognitive function.Results:Compared with the control group,hypertension and diabetes were more common in the LA group and there was a significant difference(P<0.05).MMSE and MoCA scores in the moderate and severe LA subgroups were significantly lower than those in the control group(P<0.05).Meanwhile,there was a significant difference between the LA group and control group in seven cognitive domains including visual space and execution,depending on-named ability,attention,language ability,abstract ability,delayed memory ability and directional power ability(P<0.05).The ARWMCRs score in the LA group was negatively correlated with the MMSE score and MoCA score.Conclusion:Leukoaraiosis is closely associated with cognitive function in old patients.