| 有氧运动对睡眠剥夺大鼠学习记忆及海马神经元突触可塑性的效果 |
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| 引用本文： | 李童,方志鹏,邵玉萍,王平.有氧运动对睡眠剥夺大鼠学习记忆及海马神经元突触可塑性的效果[J].中国康复理论与实践,2022,28(11):1270-1277. |
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| 作者姓名： | 李童 方志鹏 邵玉萍 王平 |
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| 作者单位： | 1.湖北中医药大学基础医学院，湖北武汉市 4300652.湖北中医药大学体育健康学院，湖北武汉市 4300653.湖北中医药大学老年医学研究所，湖北武汉市 430065 |
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| 基金项目： | 科技部重点研发计划项目(2018YFC1705600) |
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| 摘 要： | 目的 探讨有氧运动对睡眠剥夺大鼠定位巡航活动和空间探索活动，海马区神经元形态，海马神经元树突棘密度、突触相关蛋白，以及海马区环磷酸腺苷反应元件结合蛋白(CREB)/脑源性神经营养因子(BDNF)信号通路的影响。
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| 关 键 词： | 睡眠剥夺 有氧运动 突触可塑性 学习记忆 大鼠 |
| 收稿时间： | 2022-10-29 |
Effect of aerobic exercise on learning and memory,and synaptic plasticity of hippocampal neurons for sleep-deprived rats |
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| LI Tong,FANG Zhipeng,SHAO Yuping,WANG Ping.Effect of aerobic exercise on learning and memory,and synaptic plasticity of hippocampal neurons for sleep-deprived rats[J].Chinese Journal of Rehabilitation Theory and Practice,2022,28(11):1270-1277. |
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| Authors: | LI Tong FANG Zhipeng SHAO Yuping WANG Ping |
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| Institution: | 1. School of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China2. School of Physical and Health Education, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China3. Institute of Geriatrics, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China |
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| Abstract: | Objective To investigate the effects of aerobic exercise on sleep-deprived rats positioning cruise and space exploration activities, synaptic mechanism, involving hippocampal neuron morphology, dendritic spine density, synaptic related proteins and cyclic adenosine phosphate reactive element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway. |
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| Keywords: | sleep deprivation aerobic exercise synaptic plasticity learning and memory rats |
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