| 人神经干细胞移植治疗重度视觉障碍脑瘫患儿的临床观察 |
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| 引用本文： | 栾佐,屈素清,刘卫鹏,胡晓红,尹国才,金真,龚小军.人神经干细胞移植治疗重度视觉障碍脑瘫患儿的临床观察[J].中国康复理论与实践,2007,13(12):1103-1105. |
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| 作者姓名： | 栾佐 屈素清 刘卫鹏 胡晓红 尹国才 金真 龚小军 |
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| 作者单位： | 1. 海军总医院儿科,北京市,100037
2. 解放军306医院,北京市,100101 |
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| 摘 要： | 目的观察人神经干细胞(NSCs)移植治疗脑性瘫痪(CP)合并重度视觉障碍患儿的临床疗效。方法取孕11周正常发育人胚胎前脑细胞,经体外培养扩增为人神经干细胞球,并经前囟穿刺注入7例严重视觉障碍CP患儿的脑室。结果移植后,4例患儿在很短时间即出现视觉功能改善,伴有闪光视觉诱发电位、功能核磁的改变。结论人NSCs移植对部分重度视觉障碍脑瘫患儿有治疗作用。
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| 关 键 词： | 神经干细胞 移植 视觉障碍 脑性瘫痪 |
| 文章编号： | 1006-9771（2007）12-1103-03 |
| 收稿时间： | 2007-02-15 |
| 修稿时间： | 2007-09-25 |
Treatment of Heteroptics after Cerebral Palsy with Transplantation of Human Neural Stem Cells into Cerebral Ventricle in Infants: 7 Case Report |
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| LUAN Zuo , QU Su-qing , LIU Wei-peng ,et al..Treatment of Heteroptics after Cerebral Palsy with Transplantation of Human Neural Stem Cells into Cerebral Ventricle in Infants: 7 Case Report[J].Chinese Journal of Rehabilitation Theory and Practice,2007,13(12):1103-1105. |
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| Authors: | LUAN Zuo QU Su-qing LIU Wei-peng |
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| Institution: | LUAN Zuo , QU Su-qing , LIU Wei-peng , et al. |
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| Abstract: | Objective To investigate the clinical effect of human neural stem cells transplantation on severe visual disability infants after cerebral palsy. Methods Cells obtained from the forebrain of an 11-week-old abortive fetus were cultured and expanded for 15 days, then injected into cerebral ventricle of 7 patients. Results Their vision of 4 patients improved, as well as changes of flash visual evoked potential and functional magnetic resonance imaging in a few days after transplantation. Conclusion Neural stem cells transplantation may benefit in some CP children with severe visual disability. |
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| Keywords: | neural stem cells transplantation visual disability cerebral palsy |
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