重复经颅磁刺激治疗脑卒中后抑郁对照研究

目的探讨重复经颅磁刺激治疗脑卒中后抑郁患者的临床疗效。方法将120例脑卒中后抑郁患者随机分为两组，每组60例，两组均接受神经内科常规治疗，研究组联合重复经颅磁刺激治疗，连续治疗1个月，观察6个月。治疗前后采用脑卒中患者临床神经功能缺损程度评分标准评定神经功能缺损状况，采用汉密顿抑郁量表评定抑郁状况。结果治疗1个月、6个月末，研究组汉密顿抑郁量表评分显著低于对照组（u=22．91、19．23，P〈0．01），神经功能恢复效果显著优于对照组（Х^2=6．99、6．92，P〈0．05）。结论重复经颅磁刺激治疗能显著改善脑卒中后抑郁患者的抑郁情绪，有利于神经功能的恢复。

A control study of rTMS treatment in post-stroke depression

Objective To Explore the efficacy of repetitive transcranial magnetic stimulation （rTMS） treatment in patients with post-stroke depression （PSD）. Methods A total of 120 PSD patients were randomly assigned to two groups of 60 ones each, both groups received neuro-medical routine treatment, research group was plus rTMS, was continuously treated for 1 month and observed for 6 months. Neurologic impairments were assessed with the Clinical Neurologic Deficit Scale in Stroke Patient （CNDSSP） and depressive conditions with the Hamilton Depression Scale （HAMD） before and after treatment. Results At the end of the 15t and 6th month, the HAMD score was significantly lower （u= 22.91,19.23,P〈0.01） and rehabilitation result of nervous function better （Х^2= 6.99, 6.92,P〈0.05） in research than control group. Conclusion The rTMS treatment could notably improve depressive emotion of PSD patient and is beneficial to recovery of nervous function.