西酞普兰联合心理干预治疗老年支气管哮喘伴焦虑障碍对照研究

目的探讨西酞普兰联合心理干预治疗老年支气管哮喘伴发焦虑患者的临床疗效和安全性。方法将70例老年支气管哮喘伴发焦虑患者随机分成两组，每组35例，两组均接受支气管哮喘的常规治疗、康复训练，研究组口西酞普兰联合心理干预治疗，对照组口服西酞普兰治疗。观察6周。采用汉密顿焦虑量表评定焦虑状况，副反应量表评定不良反应。结果治疗6周末，研究组抗焦虑有效率为88．6％，对照组为68．6％，研究组显著高于对照组（Х^2=4．16，P〈0．05）。两组不良反应较轻微，发生率比较差异无显著性（P〉0．05）。结论西酞普兰联合心理干预治疗老年支气管哮喘伴发焦虑患者疗效显著，安全性高，依从性好，优于单用西酞普兰治疗。

A control study of citalopran plus mental intervention in the treatment of senile bronchial asthma with anxiety

Objective To explore the efficacy and safety of citaiopran plus mental intervention m ine treatment of senile bronchial asthma with anxiety. Methods Seventy senile bronchial asthma patients with anxiety were randomly divided into two groups of 35 ones each, both groups received routine treatment and rehabilitation training for bronchial asthma, research group took orally citalopran combined with mental intervention, and control group did citalopran for 6 weeks. Anxiety conditions were assessed with the Hamilton Anxiety Scale （HAMA） and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results At the end of the 6^th week, effective rate was significantly higher in research than control group （88.6% vs. 68.6% ,Х^2 =4.16 ,P〈0. 05）. Adverse reactions of both groups were mild and their incidences had no significant group differences （P〈0.05）. Conclusion Citalopran plus mental interven tion has an evident effect, higher safety and better compliance compared with single citalopran in the treatment of senile bronchial asthma with anxiety.