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文拉法辛与氟西汀治疗老年抑郁症对照研究
引用本文:彭妍.文拉法辛与氟西汀治疗老年抑郁症对照研究[J].临床心身疾病杂志,2008,14(4):320-322.
作者姓名:彭妍
作者单位:常德市康复医院,湖南常德,415000
摘    要:目的探讨文拉法辛与氟西汀治疗老年抑郁症的疗效及安全性。方法将60例老年抑郁症患者随机分为两组各30例,研究组口服文拉法辛治疗,对照组口服氟西汀治疗,观察8w。于治疗前及治疗1w、2w、4w、6w、8w末采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果治疗8w末,研究组总有效率93.3%,对照组为86.7%,两组总体疗效相当(χ^2=0.185,P〉0.05)。汉密顿抑郁量表评分,研究组治疗1w末起,对照组治疗2w末起较治疗前有显著下降(P〈0.05或0.01),研究组治疗1w、2w末较对照组下降显著(P〈0.05),其他时点评分均无显著性差异(P〉0.05)。两组不良反应均轻微。结论文拉法辛治疗老年抑郁症的疗效与氟西汀相当,且起效较氟西汀快,安全性高,依从性好。

关 键 词:老年抑郁症  文拉法辛  氟西汀  临床疗效  安全性

A control study of venlafaxine vs fluoxetine in the treatment of elderly depression
Peng Yan.A control study of venlafaxine vs fluoxetine in the treatment of elderly depression[J].Journal of Clinical Psychosomatic Diseases,2008,14(4):320-322.
Authors:Peng Yan
Institution:Peng Yan ( Changde Rehabilitation Hospital, 415000, Hunan , China)
Abstract:Objective To explore the efficacy and safety of venlafaxine and fluoxetine in the treatment of elderly patients with depression.Methods 60 patients were randomly divided into research group(n=30)took orally venlafaxine and control group(n=30)did fluoxetine for 8 weeks.Efficacies were assessed with the Hamilton Depression Scale(HAMD)and adverse reactions with the Treatment Emergent Symptom Scale(TESS)before treatment and at the ends of the 1st,2nd,4th,6th,and 8th week.Results After 8 week treatment,total effective rates were respectively 93.3% in the research and 86.7% in the control group,the total efficacies of both groups were equivalence(P>0.05).The HAMD scores lowered more significantly since the end of the 1st week in the research and of the 2nd in the control group compared with pre-treatment(P<0.05 or 0.01),did more significantly in the research than in the control group at the end of the 1st and 2nd week(P<0.05),and there were no significant differences at other time-points(P>0.05).Adverse reactions of both groups were mild.Conclusion Venlafaxine has therapeutic equivalence to fluoxetine,but takes effects quicker and has higher safety and better compliance in the treatment of elderly depression,and deserves to be extended and utilized clinically.
Keywords:Eelderly-depression  venlafaxine  fluoxetine  clinical efficacy  safety
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