朗格汉斯细胞组织细胞增生症临床病理特征分析

目的探讨朗格汉斯细胞组织细胞增生症的临床病理特征。 方法回顾性分析2016年1月至2021年9月泰安市中心医院病理科确诊的5例朗格汉斯细胞组织细胞增生症患者的临床资料，分析其病理形态学特点及免疫表型。 结果男性2例，女性3例；3例累及骨组织，1例累及腭部软组织，1例累及淋巴结；形态学均表现为肿瘤细胞呈圆形或卵圆形，有核沟，细胞质轻度嗜酸性，背景为数量不等的嗜酸性粒细胞、组织细胞、小淋巴细胞及中性粒细胞。免疫表型方面，肿瘤细胞一致性表达CD4、CD1α及S-100。 结论朗格汉斯细胞组织细胞增生症是一种少见的朗格汉斯细胞克隆性增生性病变，免疫组织化学表达稳定，选择合适的免疫组织化学抗体并结合病理形态学特征方能正确诊断。

Clinicopathological characteristics of Langerhans cell histiocytosis

ObjectiveTo explore the clinicopathological features of Langerhans cell histiocytosis(LCH). MethodsThe clinical data of 5 LCH patients who were diagnosed from January 2016 to September 2021 in the Pathology Department at Taian City Center Hospital were analyzed retrospectively, and the pathological characteristics and immunophenotype were analyzed. ResultsThere were 2 males and 3 females patients. Three cases involved bone, 1 case involved oral soft tissue, and 1 case involved the lymph node. The tumor cells had a round or oval shape with a nucleated sulcus, and a weakly eosinophilic cytoplasm, with varied amounts of neutrophils, histiocytes, tiny lymphocytes, and eosinophils in the background. Tumor cells consistently expressed CD4, CD1α and S-100 according to their immunophenotype. ConclusionsLCH, a rare Langerhans cell proliferative lesion, has a stable immunohistochemistry expression. By choosing the proper immunohistochemistry antibody and combining it with pathomorphological markers, the correct diagnosis can be obtained.