氯吡格雷治疗急性非ST段抬高心肌梗死的临床观察

目的：观察氯吡格雷治疗急性非ST段抬高心肌梗死（NSTEMI）的临床疗效及安全性。方法：急性非ST段抬高心肌梗死（NsrITEMI）60例随机分为治疗组和对照组，对照组采用低分子肝素、阿司匹林及其他抗心绞痛药物，治疗组在以上治疗的基础上加用氯吡格雷首次顿服300mg，次日起75mg／d，连服2周。结果：治疗组能明显减少心绞痛发作频率（P〈0．05），改善临床症状，对改善缺血性ST段压低明显优于对照组（P〈0．05），且对出、凝血指标影响不大（P〉0．05）。结论：在常规抗心绞痛治疗基础上加用氯吡格雷对NSTEMI安全有效。

Clinical Observation of Therapy of Clopidogrel to Acute Non-ST Elevation Myocardial Infarction

Objective: To observe the clinical effect and safety in treatment of non-ST elevation myocardial infarction(NSTEMI) with clopidogrel. Methods: 60 patients with acute NSTEMI were divided into treatment and control group randomly. Control group was administered by Low Molecular Heparin, Aspirin and other anti-anginal drugs. Clopidogrel initial doses of 300 mg and followed 75 mg/d for two weeks were combined in treatment group. Results: Treatment group significantly reduction of rate of cardiac angina (P < 0.05). Clinical symptoms and ischemic ST segment depression were improved than control group(P < 0.05), and had a small influence on index of blood clotting (P > 0.05).Conclusions: The addition of clopidogrel to basic anti-cardiac angina treatment would be more effective and safety to NSTEMI.