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Rescue of auditory function by a single administration of AAV-TMPRSS3 gene therapy in aged mice of human recessive deafness DFNB8
Institution:1. Department of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, MA 02115, USA;2. Department of Otolaryngology-Head and Neck Surgery, Graduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA;3. Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114, USA;4. Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;5. Mouse Genome Engineering Core Facility, University of Nebraska Medical Center, Omaha, NE 68198, USA;6. Kansas University Center for Hearing and Balance Disorders, Kansas City, KS 66160, USA
Abstract:
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  • Keywords:gene therapy  genetic hearing loss  DFNB8  DFNB10  recessive  TMPRSS3  AAV  aged mouse  hair cells  spiral ganglion neurons
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