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AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9
Institution:1. Department of Bioengineering, Rice University, Houston, TX 77030, USA;2. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
Abstract:
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  • Keywords:gene therapy  SaCas9  AAV-CRISPR  CD8+ T cell  immune response  somatic genome editing  hepatocytes  adeno-associated virus  pre-existing immunity  liver
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