Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine |
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Authors: | Giovanna Gentile Serena Missori Marina Borro Alisa Sebastianelli Maurizio Simmaco Paolo Martelletti |
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Institution: | (1) Department of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy;(2) Department of Medical and Molecular Sciences, Regional Referral Headache Center, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy; |
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Abstract: | Chronic migraine (CM) prevalence ranges around 1–5%. Most of these patients usually treat their acute attacks with triptans,
whose efficacy is extremely variable. A genetic basis for migraine is evident and many susceptibility genes have been described,
as well as gene polymorphisms possibly implied in therapy response. Several factors could be involved in the evolution of
episodic migraine into a chronic form, such as natural history, psychiatric comorbidity, and the individual’s response to
therapy. During a study aimed at detecting connections between genotype and response to triptans administration, we characterized
a CM population for polymorphisms in the genes coding for monoamine oxidase A, g-protein beta 3 and the cytochromes CYP3A4
and CYP1A2. Alleles and genotypes distributions were compared with known frequencies of healthy Caucasian populations. A significant
association with CM was found for the long allele of monoamine oxidase A 30 bp VNTR and CYP1A2*1F variant. Such genomic analysis
is part of an integrated platform able to evaluate different levels of metabolic pathways of drugs in CM and their influence
in the chronicization process. |
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Keywords: | Chronic migraine Triptans Pyrosequencing Pharmacogenomics Genetic liability |
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