体外高频热疗联合顺铂胸腔内注射治疗恶性胸腔积液的疗效观察及护理

目的 观察体外高频热疗联合顺铂胸腔内注射治疗恶性胸腔积液的疗效.方法 采用随机分组的方法,将68例患者分为治疗组(高频热疗+顺铂+地塞米松)、对照组(顺铂+地塞米松),两组治疗前均经B超测量胸腔积液的量,并定点穿刺抽液,4周后复查B超进行疗效评价.结果 治疗组的近期疗效为89.47%,对照组为63.33%,两组疗效有显著性差异(P＜0.05).不良反应:在血液学毒性及胃肠道反应方面,两组无显著性差异;热疗组胸痛的发生率相对较低,程度较轻,缓解时间较短,且治疗组无明显烧伤现象,仅2例患者皮肤轻度发红,24 h内自行消失.结论 体外高频热疗联合顺铂胸腔内注射治疗恶性胸腔积液是一种简单方便、安全可靠、不良反应少、患者易于接受且疗效满意的治疗措施,值得推荐使用.

Efficacy study and nursing observation of hypertherrnotherapy combined with cisplatin injected into thoracic cavity in the treatment of malignant pleural effusion

Objective To evaluate the efficacy of hyperthermotherapy plus cis-platinum (DDP) in the treatment of pleural effuion from malignant neoplams. Methods Sixty-eight cancer patients with pleural effuion were divided into two groups. Group A was treated with DDP and dexamethasone injected into thoracic cavity plus hyperthermotherapy. Group B was treated with DDP and dexamethasone into thoracic cavity alone. Four weeks later, the efficacy was evaluated by UCG. Results The efficacy of control pleural effuion of Group A was 89. 47 %, and Group B was 63. 33 % ( P ＜ 0. 05 ) respectively. These were no difference between two group in toxity and gastrointestinal side effects. Only two cases of group A showed light red skin, both dispearing in 24 h. Conclusions The combination use of hyperthermotherapy and DDP shows evidence of synergitic and additional effect. It can improve the patients life quality. It is worth further studying.