乳房自检对乳腺癌早期诊断及其预后作用的Meta分析

目的旨在评价乳房自我检查（BSE）对乳腺癌早期诊断及其预后的有效性。方法采用Cochrane系统评价的方法，全面检索有关乳房自我检查效果的随机对照试验（RCTs）和临床对照试验（CCTs）。经筛选后对纳入文献进行质量评价，按照制定的策略提取资料后用RevMan5．0进行Meta分析。结果共纳入7篇文献，其中1篇为CCTs，6篇为RCTs。结果显示，与无乳房自检相比，BSE可显著提高乳腺活检率及乳腺良性病变的检出率，而对乳腺癌死亡率影响不明显。结论BSE对乳腺癌早期诊断具有一定的辅助价值，而对于患者预后作用甚微。上述结论仍需更多设计严谨的多中心随机对照试验来证实。

Effectiveness of breast self-examination in diagnosis and prognosis of breast cancer: A Meta-analysis of case-control studies

Objective To evaluate the effectiveness of breast self-examination (BSE) in diagnosis and prognosis of breast cancer. Methods Randomized controlled trials and controlled clinical trials on effectiveness of BSE were searched. Qualified studies were enrolled and RevMan5.0 was used to perform data analysis.Results Meta analysis results suggested that: compared with no breast self-examination, BSE had a statistically significant benefit in improving breast biopsy rate and detection rate of benign lesions, while no benefit in breast cancer mortality. Conclusions BSE plays an auxiliary role in the early diagnosis of breast cancer, while little benefit in the prognosis of patients.