| 对氧磷酶基因多态性与脑梗死关联性的探讨 |
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| 引用本文： | 朱扬,吴洁敏,孙家兰,蔡健,颜静,金小燕,卢钟娇,倪培华,傅毅.对氧磷酶基因多态性与脑梗死关联性的探讨[J].诊断学,2013,12(1):90-94. |
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| 作者姓名： | 朱扬 吴洁敏 孙家兰 蔡健 颜静 金小燕 卢钟娇 倪培华 傅毅 |
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| 作者单位： | 上海市第二人民医院神经内科;上海交通大学医学院附属瑞金医院检验系;上海市公利医院神经内科;上海市第二人民医院内分泌科;上海交通大学医学院附属瑞金医院神经内科; |
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| 基金项目： | 黄浦区科技攻关计划项目[(2009)HGG-18] |
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| 摘 要： | 目的:探讨我国上海地区汉族人群的对氧磷酶1(PON1)基因T-107C、PON2 Ser311Cys基因多态性与脑梗死发病乃至颈动脉硬化之间的关系。方法:采用聚合酶链反应-限制性片段长度多态性技术,检测134例脑梗死患者和103名健康对照者PON1 T-107C、PON2 Ser311Cys的多态性基因型,并研究其对脑梗死发病的影响。结果:多因素多元逐步Logistic回归分析显示,三酰甘油、总胆固醇是脑梗死的独立危险因素;同时,脑梗死组的PON1 T-107C、PON2 Ser311Cys基因型及等位基因频率分布与健康对照组间差异均有统计学意义(P
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| 关 键 词： | 对氧磷酶 基因多态性 脑梗死 机制 |
Study on relationship between paraoxonase gene polymorphism and cerebral infarction |
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| ZHU Yang,a,WU Jie-min,a,SUN Jia-lan,CAI Jian,b,YAN Jing,b,JIN Xiao-yan,a,LU Zhong-jiao,b,NI Pei-hua,a,FU Yi.Study on relationship between paraoxonase gene polymorphism and cerebral infarction[J].Journal of Diagnostics Concepts & Practice,2013,12(1):90-94. |
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| Authors: | ZHU Yang a WU Jie-min a SUN Jia-lan CAI Jian b YAN Jing b JIN Xiao-yan a LU Zhong-jiao b NI Pei-hua a FU Yi |
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| Institution: | 1a.Department of Neurology,1b.Department of Endocrinology,Shanghai Second People’s Hospital,Shanghai 200011,China;2a.Department of Laboratory Science,2b.Department of Neurology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;3 Department of Neurology,Gongli Hospital,Shanghai 200135,China |
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| Abstract: | |
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| Keywords: | Paraoxonase Gene polymorphism Cerebral infarction Mechanism |
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