胎儿心脏后区域异常与胎儿畸形的关系研究

目的 研究四腔心观心脏后区域异常与胎儿畸形的关系，探讨胎儿常规超声检查中观察心脏后区域的临床价值。方法 行产前系统超声检查的7062例胎儿，超声检查心内和心外各脏器结构，四腔心切面观察心脏后区域。结果 产前超声共发现53例胎儿四腔心观心脏后区域异常，占0.8％ (53/7062)。37例经产后尸解证实，其中内脏异位综合征73.0％(27/37),完全性内脏反位8.1％(3/37)，心脏畸形18.9％(7/37)。结论心脏后区域异常与胎儿畸形有密切的关系。四腔心观心脏后区域异常观察方法简单，可以作为产前筛查内脏转位和心血管畸形的有效超声标志。

Study on relationship between the abnormalities in the area behind the heart and fetal defects

Objective To investigate the relationship between the abnormalities in the area behind the heart in the four-chamber view and fetal defects, the clinical significance of assessment of area behind the heart in fetal screening.Methods 7062 fetuses were scanned.Area behind the heart in the four-chamber view and anatomical survey were detected.Results Fifty-three cases (0.8％, 53/7062) with abnormal sonographic findings in the area behind the heart in the four-chamber view were detected prenatally.Thirtyseven cases were confirmed by autopsy postnatally.Among these cases, 73.0％ (27/37) had heterotaxy syndrome,8.1％(3/37) had situs inversus totalis,18.9％ (7/37) had heart defects.Conclusions There is close relationship between the abnormalities in the area behind the heart and the fetal defects.This can be used as an effective and simple indicator in screening situs inversus and cardiovascular abnomalities.