191株铜绿假单胞菌对10种药物的体外抗菌活性分析

目的分析我院铜绿假单胞菌的耐药持点．指导临床用药。方法收集2004年7月～2005年6月自我院分离的191株铜绿假单胞菌，采用纸片扩散法进行药物敏感试验，数据分析采用WHONET5．3软件。结果191株铜绿假单胞菌分离株中，耐药率〈30％的抗菌药物仃哌拉西林／三唑巴坦、亚胺培南、头孢他啶、头孢吡肟和阿米卡星，其中对亚胺培南耐药率达到22．5％，ICU分离菌对哌拉西林、哌拉西林／三唑巴坦。亚胺培南、头孢他啶、头孢吡肟和阿米卡星的耐药率高于非ICU21．7％～42．6％（P〈0．05）。结论 了解铜绿假单胞菌的耐药现状，有利于为临床合理用药提供依据。

In vitro activity of 191 strains of pseudomonas aeruginosa to 10 antimicrobial agents

Objective To investigate the antibiotic resistance of pseudomonas aeruginosa isolated from our hospital during July 2004 to June 2005.Methods Disc diffusion method was used to determine the susceptibility of 191 strains of pseudomonas aeruginosa to 10 antibiotics,WHONET 5.3 was applied for analysis.Results Among 191 strains of pseudomonas aeruginosa,resistance rates to piperacillin-tazobactam,imipenem,ceftazidime,cefepime and amikacin were less than 30%.The resistance rate to imipenem reached 22.5%.Resistance rates of isolates from ICU patients to piperacillin,piperacillin-tazobactam,imipenem,ceftazidime,cefepime and amikacin were higher than those from non-ICU patients,and the difference was between 21.7 and 42.6 percentage(P<0.05).Conclusion The status of resistance of pseudomonas aeruginosa must be investigated,in order to provide evidence for clinical rational drug utilization.