子宫内膜癌961例临床病理分析

目的探讨子宫内膜癌的发病趋势和临床病理特点。方法回顾性分析天津市滨海新区塘沽妇幼保健院和天津医科大学总医院1984年至2010年收治的961例子宫内膜癌患者的临床病理资料,并分为1984-1992年、1993-2001年、2002-2010年3个时段进行对比分析。结果 1子宫内膜癌呈逐年上升趋势,3个时段发病例数也逐年增多,≤45岁患者例数逐年增多,但3个时段所占比例呈下降趋势（P〉0.05）。2发病年龄24～89岁,平均（55.8±12.8）岁,高发年龄51～60岁,占37.98%。3病理组织类型以子宫内膜样腺癌为主,占86.58%,非子宫内膜样癌逐年显著增加,占13.42%,其组织学分级、肌层浸润的深度及手术病理分期Ⅲ、Ⅳ期的比例均高于子宫内膜样腺癌,以浆液性乳头状腺癌多见,占52.71%。结论子宫内膜癌呈上升趋势,≤45岁患者例数逐年增多;非子宫内膜样癌有所增加,其分化低、侵袭性强、预后差,应高度重视。

Pathological analysis of 961 patients with endometrial carcinoma

Objective To investigate the incidence trends and pathological characteristics of endometrial carcinoma. Methods The pathological data of 961 patients with endoenrtial carcinoma in Tanggu maternal and child health hospital of Tian- jin Binhai new area and general hospital Tianjin medical university from 1984 to 2011 were retrospectively analyzed. All the pa- tients were divided according 3 periods （period 1： 1984- 1992; period 2：1993 -2001; period 3：2002 -2010） and compara- tively analyzed. Results @Patients of the endometrial carcinoma showed an increasing trend and incidence number was increas- ing year by year in 3 period （ The number of patients younger than 45 was increasing, but its proportion showed a downward trend in 3 period, P 〉 0.05 ）. （1）The age of patients with endometrial carcinoma was from 24 to 89 years old, the average age was （55.8 ± 12. 8）, and the high incidence of age was 51 -60 years old and proportion was 37.98%. @The main pathological type was endometrial adenocarcinoma, accounted for 86. 58%. Non-endometrial carcinoma increased significantly, accounted for 13.42%, the proportion in histologic grade, depth of myometrial invasion and surgical stage Ⅲ, Ⅳ were higher than endometrioid adenocarcinoma and serous papillary adenocarcinoma was more common, accounting for 52. 71%. Conclusion Patients of the endometrial carcinoma show an increasing trend, and the number of patients younger than 45 is increasing year by year; non-en- dometrial carcinoma accounting for significantly higher proportion than before, and it is poorly differentiated, more aggressive and has poor prognosis, which should be paid much more attention.