双歧杆菌三联活菌胶囊联合四联疗法治疗幽门螺杆菌所致胃溃疡的效果

目的观察双歧杆菌三联活菌胶囊联合四联疗法治疗幽门螺杆菌(Hp)所致胃溃疡的效果。方法选取2016年1月至2019年12月在郑州大学附属郑州中心医院治疗的112例Hp所致胃溃疡患者为研究对象。按照随机数字表法分为对照组与观察组,每组56例。对照组采取四联疗法(雷贝拉唑钠+胶体果胶铋+克拉霉素+阿莫西林)治疗;观察组在对照组基础上,联合双歧杆菌三联活菌胶囊治疗。比较两组患者的临床疗效、Hp根除率、不良反应及复发率。结果观察组患者的治疗总有效率(98.21%,55/56)高于对照组(85.71%,48/56),差异有统计学意义(P<0.05)。观察组患者的Hp根除率(92.96%,52/56)高于对照组(76.79%,43/56),观察组复发率(3.57%,2/56)低于对照组(16.07%,9/56),差异均有统计学意义(P<0.05)。结论联合应用双歧杆菌三联活菌胶囊、四联疗法可提高治疗效果及Hp根除率,减少病情复发,且安全性良好。

Effect of Bifidobacterium triple viable capsules combined with quadruple therapy on gastric ulcer caused by Helicobacter pylori

Objective To observe the effect of Bifidobacterium triple viable capsules combined with quadruple therapy on gastric ulcer caused by Helicobacter pylori(HP). Methods From January 2016 to December 2019, 112 patients with HP induced gastric ulcer in Zhengzhou Central Hospital Affiliated to Zhengzhou University were selected as the research objects. They were randomly divided into control group and observation group, with 56 cases in each group. The control group was treated with quadruple therapy(rabeprazole sodium+colloidal bismuth pectin+ clarithromycin+amoxicillin). The observation group was treated with Bifidobacterium triple viable capsules on the basis of the control group. The clinical efficacy, HP eradication rate, adverse reactions and recurrence rate of the two groups were compared. Results The total effective rate of the observation group(98.21%, 55/56) was higher than that of the control group(85.71%, 48/56), the difference was significant(P<0.05).The HP eradication rate of observation group(92.96%, 52/56) was higher than that of control group(76.79%, 43/56), the recurrence rate of the observation group(3.57%, 2/56) was lower than that of the control group(16.07%, 9/56), the differences were significant(P<0.05). Conclusions Combined application of Bifidobacterium triple viable capsules and quadruple therapy can improve the treatment effect and HP eradication rate, reduce the recurrence of the disease, and has good safety.