炙甘草汤和生脉散加减治疗小儿气阴亏虚型病毒性心肌炎的临床观察

目的探讨炙甘草汤和生脉散加减治疗小儿气阴亏虚型病毒性心肌炎(VMC)的临床效果。方法选取2018年3月至2020年3月于灵宝市第一人民医院接受治疗的93例气阴亏虚型VMC患儿,依据抽签法分为对照组(n=46)与观察组(n=47)。两组均接受常规治疗,在此基础上,对照组采用灸甘草汤治疗,观察组采用炙甘草汤和生脉散加减治疗,治疗30 d后,比较两组中医症候积分、炎性指标及心肌标志物。结果治疗30 d后,两组中医症候积分、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗30 d后,两组肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、N末端脑钠肽前体(NT-proBNP)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论气阴亏虚型VMC患儿采用炙甘草汤和生脉散加减治疗效果显著,可有效抑制机体炎性反应,修复坏死的心肌细胞,有利于促进临床体征恢复。

Effect of Zhigancao Decoction combined with Shengmai Powder on viral myocarditis of Qi Yin deficiency type in children

Objective To investigate the clinical effect of Zhigancao Decoction and Shengmai Powder on viral myocarditis(VMC) of Qi Yin deficiency type in children.Methods A total of 93 children with VMC of Qi Yin deficiency type who were treated in the First People’s Hospital of Lingbao from March 2018 to March 2020 were selected and divided into control group(n=46) and observation group(n=47) according to the drawing method. On this basis, the control group was treated with moxibustion licorice decoction, and the observation group was treated with Zhigancao Decoction and Shengmai Powder. After 30 days of treatment, the TCM symptom scores, inflammatory indexes and myocardial markers were compared between the two groups. Results After 30 days of treatment, the TCM symptom score, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) levels in the two groups were lower than those before treatment, and those of the observation group were lower than those of the control group, the differences were significant(P<0.05). After 30 days of treatment, the levels of CK-MB, cTnI and NT proBNP in the two groups were lower than those before treatment, and those of the observation group were lower than those of the control group, the differences was significant(P<0.05). Conclusions Zhigancao Decoction and Shengmai Powder can effectively inhibit the inflammatory reaction, repair the necrotic myocardial cells and promote the recovery of clinical signs.