首页 | 本学科首页   官方微博 | 高级检索  
检索        

血流动力学双室模型Extended Tofts Linear在脑胶质瘤DCE-MRI渗透性定量分析的复测性及有效性研究
引用本文:贾龙威,牛蕾,马文帅,刘学军,冯卫华,隋庆兰.血流动力学双室模型Extended Tofts Linear在脑胶质瘤DCE-MRI渗透性定量分析的复测性及有效性研究[J].磁共振成像,2015(8):571-574.
作者姓名:贾龙威  牛蕾  马文帅  刘学军  冯卫华  隋庆兰
作者单位:青岛大学医学院附属医院放射科,青岛,266000
基金项目:青岛市科技局民生项目(编号14-2-3-7-nsh)
摘    要:目的通过重复测量脑胶质瘤动态对比增强磁共振成像(dynamic contrast-enhanced MRI,DCE-MRI)渗透参数:容积转运系数Ktrans、血管外细胞外间隙容积比Ve及对比剂血浆容积Vp,探讨血流动力学双室模型Extended Tofts Linear的复测性(reproducibility)。材料与方法收集经病理证实的脑胶质瘤患者19例(低级别7例,高级别12例),术前均行DCE-MRI检查。由两名工作经验丰富的放射科医师分别使用Extend Tofts Linear模型对DCE-MRI图像进行血管渗透性定量分析,获取病变实性成分的T1加权信号时间-浓度曲线及血流动力学参数Ktrans、Ve及Vp,分别记为测量1、测量2,经统计学分析,分别比较两组各参数在高、低级别胶质瘤中是否存在统计学差异以及后处理模型的复测性。结果测量1、测量2两组高级别胶质瘤的Ktrans值、Ve值及Vp值均高于低级别胶质瘤,差异均有统计学意义(P0.05)。测量1、测量2两组Ktrans值、Ve值及Vp值可重复性比较的组内相关系数(ICC)值分别为0.93、0.809、0.592,均大于0.4。结论血流动力学双室模型Extended Tofts Linear在脑胶质瘤DCE-MRI血管渗透性定量分析具有很好的复测性。

关 键 词:血流动力学  磁共振成像  动态增强    胶质瘤

The reproducibility study of the pharmacokinetic model extended tofts linear of the dynamic contrast-enhanced MRI in brain glioma
Abstract:AbstractObjective:Through repeatedly measuring the dynamic contrast- enhanced MRI (DCE-MRI) pharmacokinetic parameters-volume transfer constant, Ktrans; extracellular extravascular volume fraction, Ve; and blood plasma fraction, Vp of the glioma to determine whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably. Materials and Methods:Nineteen cases of gliomas (seven with low-grade, twelve with high-grade) were enrolled. All of the patients underwent DCE-MRI before operation. The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas, the tissue enhancement–time curve and pharmacokinetic parameters (Ktrans, Ve and Vp) of the lesion, solid components were obtained. Ktrans value, Ve value and Vp value were compared to judge whether there were signiifcant differences between the low-grade glioma and the high-grade glioma of the two groups (survey one and survey two), and whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably.Results:The values of Ktrans, Ve and Vp in high-grade glioma were signiifcantly higher than the low grade glioma in both groups (survey one and survey two), (P<0.05); The intraclass correlation coefifcient (ICC) values of Ktrans, Ve and Vp were 0.93, 0.809, 0.592, separately>0.4.Conclusion:The reproducibility of the DCE-MRI Extended Tofts Linear is good.
Keywords:Hemodynamics  Magnetic resonance imaging  Dynamic enhancement  Brain  Glioma
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号