| 酰胺质子转移成像原理及其在脑胶质瘤中的研究进展 |
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| 引用本文： | 刘晓燕,王宝剑,张娟,倪琳,马千里,谢元忠,李秀娟.酰胺质子转移成像原理及其在脑胶质瘤中的研究进展[J].磁共振成像,2022,13(2):127-129. |
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| 作者姓名： | 刘晓燕 王宝剑 张娟 倪琳 马千里 谢元忠 李秀娟 |
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| 作者单位： | 山东第一医科大学(山东省医学科学院),泰安 217000;泰安市中心医院医学影像中心,泰安 217000;山东第一医科大学(山东省医学科学院),泰安 217000;山东第一医科大学第二附属医院医学影像科,泰安 217000;泰安市中心医院医学影像中心,泰安 217000 |
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| 摘 要： | 脑胶质瘤是中枢神经系统最常见的原发性肿瘤,死亡率及术后复发率较高,目前常规磁共振成像技术已无法满足其临床诊断及治疗决策的需要.酰胺质子转移(amide proton transfer,APT)成像通过探测体内游离蛋白质及多肽链中酰胺质子与水中氢质子交换速率从而在分子水平反映细胞中蛋白质含量及酸碱度变化,可弥补常规磁共振...
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| 关 键 词： | 胶质瘤 酰胺质子转移 化学交换饱和转移 磁共振成像 |
Principle of amide proton transfer imaging and its research progress in glioma |
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| LIU Xiaoyan,WANG Baojian,ZHANG Juan,NI Lin,MA Qianli,XIE Yuanzhong,LI Xiujuan.Principle of amide proton transfer imaging and its research progress in glioma[J].Chinese Journal of Magnetic Resonance Imaging,2022,13(2):127-129. |
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| Authors: | LIU Xiaoyan WANG Baojian ZHANG Juan NI Lin MA Qianli XIE Yuanzhong LI Xiujuan |
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| Institution: | (Shandong First Medical University(Shandong Academy of Medical Sciences),Tai'an 217000;Medical Imaging Center of Tai'an Central Hospital,Tai'an 217000;Department of Radiology,the Second Affiliated Hospital of Shandong First Medical University,Tai'an 217000) |
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| Abstract: | Glioma is the most common primary tumor of the central nervous system,high mortality and postoperative recurrence rate.At present,conventional magnetic resonance imaging technology can not meet the needs of clinical diagnosis and treatment decision-making.Amide proton transfer(APT)imaging can reflect the protein content and pH changes in cells at the molecular level by detecting the exchange rate of amide protons in free proteins and polypeptide chains in vivo with hydrogen protons in water,which can make up for the shortcomings of conventional magnetic resonance imaging technology.In recent years,APT imaging technology has been gradually applied in central nervous system diseases,especially in the early diagnosis,preoperative grading and curative effect evaluation of glioma.This paper mainly expounds the basic principle of APT imaging technology and its research progress in glioma. |
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| Keywords: | glioma amide proton transfer chemical exchange saturation transfer magnetic resonance imaging |
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