磁共振扩散成像在脑胶质瘤预后预测的研究进展

脑胶质瘤是中枢神经系统最常见的恶性肿瘤,不同病理级别及基因型的脑胶质瘤预后差别很大。MR扩散成像通过检测水分子的微观运动反映组织结构的变化,对于脑胶质瘤预后预测有着重要的临床意义。扩散张量成像、扩散峰度成像、体素内非相干运动成像、拉伸指数模型扩散加权成像、超高b值DWI成像、神经突起方向离散度与密度成像等可以定量检测组织内水分子的扩散信息,反映肿瘤的异质性及细胞增殖情况,这为准确预测脑胶质瘤预后提供了新的思路。作者对MR扩散成像在脑胶质瘤预后预测的研究进展进行综述。

MR diffusion imaging:research advances in prognosis prediction of gliomas

Glioma is the most common malignant tumor in central nervous system.The prognosis of glioma varies greatly with different pathological grades and genotypes.MRI diffusion imaging reflects the changes of tissue structure by detecting the micro movement of water molecules,which has important clinical significance for the prognosis prediction of glioma.Diffusion tensor imaging(DTI),diffusion kurtosis imaging(DKI),intravoxel incoherent motion(IVIM),stretched exponential model diffusion-weighted imaging(SEM DWI),ultra-high b-value DWI imaging and neurite orientation dispersion and density imaging(NODDI)can quantitatively detect the diffusion information of water molecules in tissues,reflect the heterogeneity of tumor and cell proliferation,which provides new ideas for accurately predicting the prognosis of glioma.This paper reviews the research progress of MRI diffusion imaging in predicting the prognosis of glioma.